Shagass C, Roemer R A, Straumanis J J, Amadeo M
Biol Psychiatry. 1978 Apr;13(2):163-84.
Evoked potential (EP) correlates of several psychiatric disorders were investigated by applying a comprehensive EP procedure to 102 psychiatric patients and 28 nonpatients. EPs to left and right median nerve shocks, visual pattern flashes, and auditory clicks were recorded from one EOG and 14 monopolar scalp derivations. Nine age- and sex-matched groups were compared to yield the following main results: (i) EPs of overtly psychotic patients (schizophrenics, depressives, manics) differed markedly from normal, while those of patients without overt psychosis (neurotics, personality disorders, latent schizophrenics) did not; in the overtly psychotic, later EP events (100 msec or more poststimulus) were attenuated. (ii) EPs of neurotic depressives differed greatly from those of psychotic depressives. (iii) A somatosensory negative peak occurring 60-msec poststimulus (N60) was more posteriorly distributed in chronic schizophrenics (paranoid, undifferentiated) than in any other subject group. The attenuated later EP activity associated with overt psychosis was interpreted as a concomitant of cognitive (attention?) impairment, rather than of emotional disturbance.
通过对102名精神科患者和28名非患者应用全面的诱发电位（EP）程序，研究了几种精神障碍的诱发电位相关性。从一个眼电图（EOG）和14个单极头皮导联记录了对左右正中神经电击、视觉模式闪光和听觉咔哒声的诱发电位。与9个年龄和性别匹配的组进行比较，得出以下主要结果：（i）明显精神病患者（精神分裂症患者、抑郁症患者、躁狂症患者）的诱发电位与正常人明显不同，而无明显精神病的患者（神经症患者、人格障碍患者、潜在精神分裂症患者）则没有；在明显精神病患者中，较晚的诱发电位事件（刺激后100毫秒或更长时间）减弱。（ii）神经症性抑郁症患者的诱发电位与精神病性抑郁症患者的诱发电位有很大差异。（iii）刺激后60毫秒出现的体感负峰（N60）在慢性精神分裂症患者（偏执型、未分化型）中的分布比在任何其他受试者组中更靠后。与明显精神病相关的较晚诱发电位活动减弱被解释为认知（注意力？）损害的伴随现象，而不是情绪障碍的伴随现象。
