Tukey J W, Ciminera J L, Heyse J F
Biometrics. 1985 Mar;41(1):295-301.
Experiments in which the treatments are composed of a series of doses of a compound and a zero dose control are often used in animal toxicity studies. A test procedure is proposed to assess trends in the response variable. The notion of a no-statistical-significance-of-trend (NOSTASOT) dose is introduced, and questions of multiplicity of statistical tests in this context are addressed.
在动物毒性研究中，常采用这样的实验：处理由化合物的一系列剂量和零剂量对照组成。本文提出了一种检验程序来评估反应变量的趋势。引入了无趋势统计显著性（NOSTASOT）剂量的概念，并讨论了在此背景下统计检验的多重性问题。
