İpekoğlu Gökhan, Çetin Tuğba, Sırtbaş Tülay, Kılıç Rabia, Odabaşı Mustafa, Bayraktar Fahrettin
Faculty of Sport Science, Ordu University, Ordu, Turkey.
Hasan Dogan Faculty of Sports Sciences, Karabuk University, Karabuk, Turkey.
J Physiol Biochem. 2025 Mar 8. doi: 10.1007/s13105-025-01071-0.
Recent studies have focused on genetic polymorphisms that may influence athlete status. This meta-analysis aimed to investigate the association between athlete status and specific candidate genetic polymorphisms (AGTR2 rs11091046, FTO rs9939609, GALNTL6 rs558129, GNB3 rs5443, MCT1 rs1049434, NOS3 rs2070744). Only case-control studies collected from PubMed and Web of Science databases, published between 2009 and 2022, were included. A total of 23 studies were included in the meta-analysis according to the criteria of the research, and analyses were performed using random or fixed effects models. Effect size, odds ratio, or risk ratio were evaluated with a suitable 95% confidence interval. The results showed that the GALNTL6 rs558129 T/T genotype, MCT1 rs1049434 T/T genotype, and NOS3 rs2070744 T allele and T/T genotype were more prevalent in power athletes than in controls (p < 0.05). Conversely, the GALNTL6 rs558129 C allele, C/C genotype, and AGTR2 rs11091046 C allele and C/C genotype were more common in the control group. These findings indicate that some genetic polymorphisms may be important markers in athlete status and should be supported by future studies.
最近的研究集中在可能影响运动员身份的基因多态性上。这项荟萃分析旨在研究运动员身份与特定候选基因多态性（AGTR2 rs11091046、FTO rs9939609、GALNTL6 rs558129、GNB3 rs5443、MCT1 rs1049434、NOS3 rs2070744）之间的关联。仅纳入2009年至2022年间发表的从PubMed和Web of Science数据库收集的病例对照研究。根据研究标准，共有23项研究纳入荟萃分析，并使用随机或固定效应模型进行分析。效应大小、优势比或风险比通过合适的95%置信区间进行评估。结果显示，GALNTL6 rs558129 T/T基因型、MCT1 rs1049434 T/T基因型以及NOS3 rs2070744 T等位基因和T/T基因型在力量型运动员中比在对照组中更普遍（p < 0.05）。相反，GALNTL6 rs558129 C等位基因、C/C基因型以及AGTR2 rs11091046 C等位基因和C/C基因型在对照组中更常见。这些发现表明，一些基因多态性可能是运动员身份的重要标志物，值得未来的研究加以支持。
