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[1-¹⁴C]辛酸酯:一种快速的脑活动功能标记物。

[1-14C]Octanoate: a fast functional marker of brain activity.

作者信息

Rowley H, Collins R C

出版信息

Brain Res. 1985 Jun 3;335(2):326-9. doi: 10.1016/0006-8993(85)90486-x.

DOI:10.1016/0006-8993(85)90486-x
PMID:4005560
Abstract

[1-14C]Octanoate (OCTO) is rapidly extracted from blood and metabolized by brain. Up to 6 min following an intravenous pulse injection the autoradiographic pattern of brain labeling reflects differences in blood flow and energy metabolism. When animals are given OCTO during visual or somatosensory stimulation the autoradiograms reveal differential labeling of activated pathways. Studies can be performed in 7-20 s allowing fast labeling of functional brain anatomy.

摘要

[1-¹⁴C]辛酸(OCTO)能迅速从血液中被提取出来并由大脑进行代谢。静脉脉冲注射后长达6分钟,大脑标记的放射自显影模式反映了血流和能量代谢的差异。当在视觉或体感刺激期间给动物注射OCTO时,放射自显影片显示出激活通路的差异标记。研究可在7 - 20秒内完成,从而实现对功能性脑解剖结构的快速标记。

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