Comer C M
Brain Res. 1985 Jun 3;335(2):342-6. doi: 10.1016/0006-8993(85)90490-1.
Individual giant interneurons (GIs) in the ventral nerve cord of the cockroach, Periplaneta americana, were lesioned by intracellular injection of proteolytic enzymes (pronase). This was accomplished with minimal dissection, so that the wind-evoked escape behavior of the animals could be studied following the lesion. Unilateral lesions of GI-2 had no obvious effect on escape behavior, but unilateral removal of GI-1, as well as combined unilateral lesions of GIs 1 and 2, influenced the direction of an animal's initial turning movement in response to a wind puff. These results support the hypothesis that GIs play a role in initiating and guiding the directional, wind-evoked escape response of the cockroach.
通过向美洲大蠊腹神经索中的单个巨型中间神经元（GIs）内注射蛋白水解酶（链霉蛋白酶）来造成损伤。这一操作在极小的解剖程度下完成，以便在损伤后研究动物的风诱发逃避行为。GI - 2的单侧损伤对逃避行为没有明显影响，但GI - 1的单侧移除以及GI - 1和GI - 2的联合单侧损伤，会影响动物对风一吹作出的初始转向运动方向。这些结果支持了以下假说：巨型中间神经元在启动和引导蟑螂对风诱发的定向逃避反应中发挥作用。
