Colli Cruz Carolina, Moura Nascimento Santos Maria Julia, Wali Sharada, Varatharajalu Krishnavathana, Thomas Anusha, Wang Yinghong
Department of Gastroenterology, Hepatology & Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Immunotherapy. 2025 Mar;17(4):293-303. doi: 10.1080/1750743X.2025.2473305. Epub 2025 Mar 7.
Immune checkpoint inhibitors (ICIs) have greatly improved cancer treatment by boosting the immune system's ability to target tumors. However, they can also cause serious side effects, particularly in the digestive system. These include immune-related diarrhea, inflammation of the intestines and, less commonly, inflammation of the stomach or esophagus. This review underscores the importance of early detection, accurate diagnosis, and timely treatment to improve patient outcomes. It also highlights the need for further research to develop strategies to reduce gastrointestinal toxicities and enhance the overall effectiveness of ICIs in cancer therapy.
免疫检查点抑制剂（ICIs）通过增强免疫系统靶向肿瘤的能力，极大地改善了癌症治疗。然而，它们也可能导致严重的副作用，尤其是在消化系统。这些副作用包括免疫相关的腹泻、肠道炎症，较少见的还有胃部或食管炎症。本综述强调了早期检测、准确诊断和及时治疗对改善患者预后的重要性。它还强调了进一步研究的必要性，以制定减少胃肠道毒性并提高ICIs在癌症治疗中整体有效性的策略。
