Noronha R F, Rao B R
Cancer. 1985 Jul 1;56(1):134-7. doi: 10.1002/1097-0142(19850701)56:1<134::aid-cncr2820560121>3.0.co;2-j.
Primary renal adenocarcinoma tissue, metastatic deposits, and normal kidney parenchyma from 16 patients were assayed for sex hormone receptors by dextran-coated charcoal adsorption and sucrose gradient centrifugation techniques. Dihydrotestosterone receptors (DHTR) were found in all renal carcinomatous tissue (20/20) and in 93% (13/14) autologous normal kidneys analyzed. Testosterone receptors were found in 84% (16/19) of tumors and 93% (14/15) or normal kidneys analyzed. Estrogen receptors in small amounts (ER) were detected in only 5% (1/19) of tumors and in 7% (1/15) of normal kidneys. Progesterone receptors (PR) in low quantities were detected in 30% (6/20) of renal tumors and in 40% (6/15) of normal kidneys. DHTR levels in high-stage tumors (T3, T4) were significantly elevated over levels in autologous normal kidney, whereas in low-stage tumors localized to the kidney (T1 and T2 tumors) DHTR levels were not significantly different from autologous normal kidney. The mean levels of DHTR in high-stage kidney tumors were significantly elevated over levels in low-stage tumors (P less than 0.001). DHTR estimation in renal neoplasms may help in biologic staging of renal adenocarcinoma and could define a group of patients in whom anti-androgen therapy may be worth a trial.
采用葡聚糖包被活性炭吸附法和蔗糖梯度离心技术，对16例患者的原发性肾腺癌组织、转移灶及正常肾实质进行了性激素受体检测。在所有肾癌组织（20/20）以及93%（13/14）的所分析的自体正常肾组织中均发现了双氢睾酮受体（DHTR）。在所分析的肿瘤组织中，84%（16/19）发现有睾酮受体，在正常肾组织中93%（14/15）发现有睾酮受体。仅在5%（1/19）的肿瘤组织和7%（1/15）的正常肾组织中检测到少量雌激素受体（ER）。在30%（6/20）的肾肿瘤组织和40%（6/15）的正常肾组织中检测到少量孕酮受体（PR）。高分期肿瘤（T3、T4）中的DHTR水平显著高于自体正常肾组织中的水平，而局限于肾脏的低分期肿瘤（T1和T2肿瘤）中的DHTR水平与自体正常肾组织无显著差异。高分期肾肿瘤中DHTR的平均水平显著高于低分期肿瘤（P<0.001）。对肾肿瘤进行DHTR评估可能有助于肾腺癌的生物学分期，并可确定一组可能值得尝试抗雄激素治疗的患者。
