Prodi G, De Giovanni C, Galli M C, Gola G, Grilli S, Rocchetta R, Orlandi C
Tumori. 1979 Apr 30;65(2):241-53. doi: 10.1177/030089167906500214.
Using the value of 0.24 fmoles/microgram DNA as breaking point between high and low binding capacities, we quantified receptors for 17 beta-estradiol (ER), 5 alpha-dihydrotestosterone (DHTR), progesterone (PR) and cortisol (CR) in normal and neoplastic human uterine tissues. Concerning receptors occurrence, significant relationships were observed between ER and PR, ER and DHTR, and DHTR and PR. A direct correlation between the presence of ER and tumor grading was found: PR was less frequent in grade II and absent in grade III endometrial carcinoma, however this was not a significant correlation. In endometrial carcinoma at least 1 of the receptors was detected in 67-91% of the cases, 3 receptors (ER, DHTR, PR) in 56%, and all 4 receptors in 45%. The simultaneous detection of multiple receptors could play an important role in determining hormone response.
以0.24飞摩尔/微克DNA作为高结合能力和低结合能力的分界点，我们对正常和肿瘤性人类子宫组织中的17β-雌二醇（ER）、5α-双氢睾酮（DHTR）、孕酮（PR）和皮质醇（CR）受体进行了定量。关于受体的出现情况，观察到ER与PR、ER与DHTR以及DHTR与PR之间存在显著关系。发现ER的存在与肿瘤分级之间存在直接相关性：PR在II级子宫内膜癌中较少见，在III级中不存在，但这不是显著相关性。在子宫内膜癌中，67%-91%的病例至少检测到1种受体，56%的病例检测到3种受体（ER、DHTR、PR），45%的病例检测到所有4种受体。多种受体的同时检测可能在确定激素反应中起重要作用。
