Kaneko Y, Kikuchi M, Ishihara A, Abe R, Takayama S, Sakurai M
Cancer. 1985 Jul 1;56(1):144-51. doi: 10.1002/1097-0142(19850701)56:1<144::aid-cncr2820560123>3.0.co;2-c.
Chromosome and pathologic studies were performed on two patients (a 12-year-old boy and a 62-year-old woman) with malignant histiocytosis (MH). Both patients had chromosome abnormalities in their neoplastic cells: the boy's karyotype was 45,Xp+,-Y,9p+,18q-, and the woman's 48,XX,+16, inv(1),mar(5),6p-,10p+,12q+,i(18q),+i(18q). The boy had typical clinical and pathologic findings of MH, and died without achieving remission by chemotherapy. At the initial stage the woman had the clinical and hematologic findings of MH. Chemotherapy was given, but had no beneficial effects. At the terminal stage the bone marrow (BM) biopsy and aspirate, and the autopsy findings, were consistent with those of non-Hodgkin lymphoma, diffuse large cell type, although some histiocytes or abnormal cells in monocyte-macrophage lineage remained in the BM and the autopsied lymph nodes. This study and a review of data on six other cases have failed to establish any specific chromosome changes in MH.
对两名恶性组织细胞增多症（MH）患者（一名12岁男孩和一名62岁女性）进行了染色体和病理研究。两名患者的肿瘤细胞均存在染色体异常：男孩的核型为45,Xp+,-Y,9p+,18q-，女性的核型为48,XX,+16,inv(1),mar(5),6p-,10p+,12q+,i(18q),+i(18q)。男孩具有典型的MH临床和病理表现，死于化疗未缓解。女性在疾病初期具有MH的临床和血液学表现。给予了化疗，但没有产生有益效果。在疾病末期，骨髓活检和穿刺以及尸检结果与弥漫大细胞型非霍奇金淋巴瘤一致，尽管骨髓和尸检淋巴结中仍存在一些单核细胞-巨噬细胞系的组织细胞或异常细胞。本研究以及对其他六例病例数据的回顾未能确定MH中任何特定的染色体变化。
