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基于术后加速康复全程管理方案的日间微创肝切除术临床实践

[Clinical practice of minimally invasive daytime hepatectomy based on enhanced recovery after surgery whole-process management scheme].

作者信息

Lin J H, Zhang Y W, Mao Q J, Liu Q F, Ge Z Y, Xu H X, Jin R A, Liang X

机构信息

Zhejiang Key Laboratory of Multi-omics Precision Diagnosis and Treatment of Liver Diseases, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

出版信息

Zhonghua Wai Ke Za Zhi. 2025 Apr 1;63(4):331-337. doi: 10.3760/cma.j.cn112139-20241031-00481.

DOI:10.3760/cma.j.cn112139-20241031-00481
PMID:40058786
Abstract

To explore the clinical effect of the whole-process management scheme of daytime minimally invasive liver resection surgery based on the enhanced recovery after surgery (ERAS) concept. This is a retrospective case series study. The data of 55 patients who underwent minimally invasive daytime liver resection surgery under the ERAS concept at the Department of General Surgery,Sir Run Run Shaw Hospital, Zhejiang University School of Medicine from January 2023 to August 2024. There were 22 males and 33 females;aged (48.2±15.1) years (range: 16 to 77 years). All patients were classified as Grade 2 according to the American Society of Anesthesiologists physical status classification. Among them, 7 cases were complicated with liver cirrhosis and 10 cases had fatty liver. A multidisciplinary team was formed, consisting of surgeons, anesthesiologists, rehabilitation physicians, psychologists, pharmacists, acute pain management team, operating room nurses, day surgery ward nurses, and ERAS specialized nurses. After strict evaluation by surgeons and anesthesiologists, patients suitable for daytime liver resection surgery were implemented with the ERAS whole-process management plan for liver resection on the basis of routine nursing care. Among the 55 patients, 50 were discharged smoothly within 48 hours, while 5 were transferred to specialized departments for further treatment due to not meeting the discharge criteria, with a smooth daytime discharge rate of 90.9%. Among the 50 patients, 30 underwent laparoscopic surgery and 20 underwent robotic-assisted surgery. The surgery time was (91.6±28.2)minutes(range:45 to 165 minutes), with the intraoperative blood loss of only (30.5±25.5)ml(range:5 to 100 ml). Pathological examination results showed that among the 50 patients, 13 cases had hepatocellular carcinoma, 21 cases had hepatic hemangioma, 4 cases had hepatic cyst, 8 cases had focal nodular hyperplasia, 1 case had low-grade dysplastic nodule, 1 case had hepatolithiasis, 1 case had lymphoma, and 1 case had vascular, fibrous and lymphoid tissue proliferation. There were 44.0% patients who were able to get out of bed on the day of surgery. The hospital stay was (1.8±0.4)days(range:1 to 2 days), and the hospitalization cost was (34 499±20 330)yuan(range:11 724 to 73 488 yuan). No complications requiring special treatment outside the conventional pathway were observed during the hospital stay and follow-up period. At the 2-week outpatient follow-up, no significant abnormalities were found in all patients, and the wound healing was good. The daytime liver resection surgery based on the ERAS whole-process management plan has shown good feasibility in clinical practice. It helps to simplify medical process, shorten hospital stay, and reduce medical costs.

摘要

探讨基于加速康复外科(ERAS)理念的日间微创肝切除手术全程管理方案的临床效果。这是一项回顾性病例系列研究。收集了2023年1月至2024年8月在浙江大学医学院附属邵逸夫医院普外科接受基于ERAS理念的日间微创肝切除手术的55例患者的数据。其中男性22例,女性33例;年龄(48.2±15.1)岁(范围:16至77岁)。所有患者根据美国麻醉医师协会身体状况分级均为2级。其中,7例合并肝硬化,10例有脂肪肝。组建了一个多学科团队,成员包括外科医生、麻醉医生、康复医生、心理医生、药剂师、急性疼痛管理团队、手术室护士、日间手术病房护士和ERAS专科护士。经外科医生和麻醉医生严格评估后,对适合日间肝切除手术的患者在常规护理基础上实施ERAS肝切除全程管理方案。55例患者中,50例在48小时内顺利出院,5例因未达到出院标准转至专科进一步治疗,日间顺利出院率为90.9%。50例患者中,30例行腹腔镜手术,20例行机器人辅助手术。手术时间为(91.6±28.2)分钟(范围:45至165分钟),术中出血量仅为(30.5±25.5)毫升(范围:5至100毫升)。病理检查结果显示,50例患者中肝细胞癌13例,肝血管瘤21例,肝囊肿4例,局灶性结节性增生8例,低级别发育异常结节1例,肝内胆管结石1例,淋巴瘤1例,血管、纤维及淋巴组织增生1例。44.0%的患者在手术当天即可下床活动。住院时间为(1.8±0.4)天(范围:1至2天),住院费用为(34499±20330)元(范围:11724至73488元)。住院期间及随访期间未观察到需要常规路径以外特殊处理的并发症。在术后2周门诊随访时,所有患者均未发现明显异常,伤口愈合良好。基于ERAS全程管理方案的日间肝切除手术在临床实践中显示出良好的可行性。有助于简化医疗流程,缩短住院时间,降低医疗费用。

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