Chung Sunglan, Lee Su-Jung, Yun Hye Sup, Lee Jae-Hoon, Kim Woo Taek
Underwood International College, Yonsei University, Seoul 03722, Korea.
Department of Biology Education, Pusan National University, Busan 46241, Korea.
BMB Rep. 2025 Apr;58(4):147-157. doi: 10.5483/BMBRep.2024-0146.
Abscisic acid (ABA) is a key phytohormone that regulates multiple biological processes in plants, including seed germination, seedling growth, and abiotic stress response. ABA enhances drought tolerance by promoting stomatal closure, thereby improving crop productivity under unfavorable stress conditions. Extensive research efforts have focused on understanding ABA signaling more clearly for its potential application in agriculture. The accumulation and stability of signaling components involved in the efficient transduction of downstream ABA signaling are affected by both transcriptional regulation and post-translational modifications. Ubiquitination is a representative post-translational modification that regulates protein stability, and E3 ubiquitin ligase is a key enzyme that determines target substrates for ubiquitination. To date, many E3 ligases functioning as a monomeric form such as RING-, HECT- and Ubox- types have been known to participate in the ABA signaling process. In this review, we summarize the current understanding of ABA-related monomeric E3 ligases, their regulation, and mode of action in Arabidopsis, which will help develop a detailed and integrated understanding of the ABA signaling process in Arabidopsis. [BMB Reports 2025; 58(4): 147-157].
脱落酸（ABA）是一种关键的植物激素，可调节植物中的多种生物学过程，包括种子萌发、幼苗生长和非生物胁迫反应。ABA通过促进气孔关闭来增强耐旱性，从而在不利的胁迫条件下提高作物产量。广泛的研究工作致力于更清楚地了解ABA信号传导，以便其在农业中的潜在应用。参与下游ABA信号高效转导的信号成分的积累和稳定性受转录调控和翻译后修饰的影响。泛素化是一种调节蛋白质稳定性的代表性翻译后修饰，E3泛素连接酶是决定泛素化靶底物的关键酶。迄今为止，已知许多以单体形式发挥作用的E3连接酶，如RING型、HECT型和Ubox型，参与ABA信号传导过程。在这篇综述中，我们总结了目前对拟南芥中与ABA相关的单体E3连接酶、它们的调控及其作用模式的理解，这将有助于对拟南芥中ABA信号传导过程形成详细而全面的认识。[《BMB报告》2025年；58(4): 147 - 157]
