Morris G M, Hopewell J W
Cell Tissue Kinet. 1985 Jul;18(4):407-15. doi: 10.1111/j.1365-2184.1985.tb00671.x.
The basal cell density (BCD), labelling index (LI), duration of DNA synthesis (TS) and cell cycle time (TC) have been calculated for the epidermis of pigs in the age range 4-27 months. The BCD declined progressively from 143.4 +/- 6.5 cells/mm at 4 months to 128.8 +/- 8.3 cells/mm at 15 months, whereafter the values showed little change. There was a small decrease in LI with increasing age, from 7.9 +/- 1.5% at 4 months to 5.9 +/- 1.0% at 27 months. However, the change to housing animals outdoors as compared with indoors had a greater effect on the LI (approximately 10%). Severe weathering in the skin of animals housed outdoors resulted in a very high LI (approximately 20%). Neither TS or TC varied significantly with age. TS was within the range 8.8-9.2 hr and TC 127-161 hr. In animals housed outdoors TC was reduced relative to animals housed indoors. The BCD and TS were not affected by housing conditions. The kinetic parameters investigated in the pig were similar to those reported for man.
已计算了4至27月龄猪表皮的基底细胞密度（BCD）、标记指数（LI）、DNA合成持续时间（TS）和细胞周期时间（TC）。BCD从4月龄时的143.4±6.5个细胞/mm逐渐下降至15月龄时的128.8±8.3个细胞/mm，此后数值变化不大。LI随年龄增长略有下降，从4月龄时的7.9±1.5%降至27月龄时的5.9±1.0%。然而，与室内饲养相比，改为户外饲养对LI的影响更大（约10%）。户外饲养动物的皮肤严重老化导致LI非常高（约20%）。TS和TC均未随年龄显著变化。TS在8.8 - 9.2小时范围内，TC在127 - 161小时范围内。与室内饲养的动物相比，户外饲养动物的TC降低。BCD和TS不受饲养条件影响。在猪身上研究的动力学参数与报道的人类参数相似。
