Nath A S, Herur Siddharth, Taduri Gangadhar, Guditi Swarnalatha, Kalidindi Raja Karthik, Murugan Prasanna, Nair Rahul R, Ganesh Niranjan
Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.
Indian J Nephrol. 2025 Mar-Apr;35(2):301-303. doi: 10.25259/ijn_413_23. Epub 2024 Jun 10.
Serological testing for M-type anti-phospholipase A2 receptor antibodies (antiPLA2R Ab) has abrogated the need for kidney biopsy to diagnose membranous nephropathy in the appropriate clinical setting. We report a case of a 63-year-old hypertensive male who presented with nephrotic syndrome associated with autosomal dominant polycystic kidney disease which was effectively diagnosed with the use of antiPLA2R Ab test. He achieved complete remission upon treatment with Rituximab. Hitherto, all anecdotal case reports of this uncommon association were diagnosed only by kidney biopsy. We highlight the usefulness of PLA2RAb especially in such cases of difficult-to-biopsy kidneys.
检测M型抗磷脂酶A2受体抗体（抗PLA2R抗体）的血清学检测方法，已使在适当临床环境下诊断膜性肾病时无需进行肾活检。我们报告一例63岁男性高血压患者，其患有与常染色体显性多囊肾病相关的肾病综合征，通过抗PLA2R抗体检测得以有效诊断。他使用利妥昔单抗治疗后实现完全缓解。迄今为止，所有关于这种罕见关联的个案报道均仅通过肾活检诊断。我们强调抗PLA2R抗体的实用性，尤其是在肾活检困难的此类病例中。
