Suppr超能文献

出血性膀胱炎的病因：BK多瘤病毒和腺病毒检测

Aetiology of haemorrhagic cystitis: BK Polyomavirus and Adenovirus detection.

作者信息

Chili Yoliswa Z, Nkosi Menzi B, Byrne Nicky-Louise, Maseko Moepeng J, Korsman Stephen N J, van Zyl Gert U

机构信息

Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa.

Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.

出版信息

S Afr J Infect Dis. 2025 Feb 11;40(1):685. doi: 10.4102/sajid.v40i1.685. eCollection 2025.

DOI:10.4102/sajid.v40i1.685
PMID:40060087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11886550/
Abstract

UNLABELLED

This case report details haemorrhagic cystitis in a 49-year-old female with chronic lymphocytic leukaemia (CLL), recurrent haematuria and detected BK polyomavirus (BKPyV) and adenovirus (HAdV) in urine. During chemotherapy cycles, quantitative polymerase chain reaction (PCR) assays found high HAdV load, similar to a HAdV-B2 genotype 78, a rare genotype that is closely related to HAdV-11.

CONTRIBUTION

Viral interactions reveal immune system vulnerabilities.

摘要

未标记

本病例报告详细介绍了一名49岁慢性淋巴细胞白血病（CLL）女性患者的出血性膀胱炎、复发性血尿以及尿液中检测到的BK多瘤病毒（BKPyV）和腺病毒（HAdV）。在化疗周期中，定量聚合酶链反应（PCR）检测发现腺病毒载量很高，类似于腺病毒B2基因型78，这是一种与腺病毒11型密切相关的罕见基因型。

贡献

病毒相互作用揭示了免疫系统的脆弱性。

相似文献

1
Aetiology of haemorrhagic cystitis: BK Polyomavirus and Adenovirus detection.出血性膀胱炎的病因：BK多瘤病毒和腺病毒检测
S Afr J Infect Dis. 2025 Feb 11;40(1):685. doi: 10.4102/sajid.v40i1.685. eCollection 2025.
2
Multiplex real-time PCR assay for simultaneous quantification of BK polyomavirus, JC polyomavirus, and adenovirus DNA.多重实时 PCR assay 用于同时定量 BK 多瘤病毒、JC 多瘤病毒和腺病毒 DNA。
J Clin Microbiol. 2010 Mar;48(3):825-30. doi: 10.1128/JCM.01699-09. Epub 2010 Jan 6.
3
The human polyomavirus BK (BKPyV): virological background and clinical implications.人类多瘤病毒 BK（BKPyV）：病毒学背景与临床意义。
APMIS. 2013 Aug;121(8):728-45. doi: 10.1111/apm.12134. Epub 2013 Jun 19.
4
BK Polyomavirus-Biology, Genomic Variation and Diagnosis.BK 多瘤病毒-生物学、基因组变异与诊断。
Viruses. 2021 Jul 30;13(8):1502. doi: 10.3390/v13081502.
5
ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients.造血干细胞移植受者中 BK 多瘤病毒相关性出血性膀胱炎的预防、诊断和治疗的 ECIL 指南。
J Antimicrob Chemother. 2018 Jan 1;73(1):12-21. doi: 10.1093/jac/dkx324.
6
Development of a droplet digital PCR assay for the detection of BK polyomavirus.开发一种用于检测 BK 多瘤病毒的液滴数字 PCR 检测方法。
Microbiol Spectr. 2024 Nov 5;12(11):e0108924. doi: 10.1128/spectrum.01089-24. Epub 2024 Oct 14.
7
Concurrent BK polyomavirus, adenovirus and cytomegalovirus infections in a patient treated for chronic lymphocytic leukaemia.慢性淋巴细胞白血病患者在治疗过程中并发 BK 多瘤病毒、腺病毒和巨细胞病毒感染。
BMJ Case Rep. 2021 Jan 5;14(1):e235981. doi: 10.1136/bcr-2020-235981.
8
Impact of BK polyomavirus viremia on the outcomes of allogeneic hematopoietic stem cell transplantation.BK多瘤病毒血症对异基因造血干细胞移植结局的影响。
Ann Hematol. 2024 May;103(5):1737-1744. doi: 10.1007/s00277-024-05707-x. Epub 2024 Mar 21.
9
Polyomavirus BK--a potential new therapeutic target for painful bladder syndrome/interstitial cystitis?多瘤病毒BK——疼痛性膀胱综合征/间质性膀胱炎潜在的新治疗靶点？
Med Hypotheses. 2014 Sep;83(3):317-20. doi: 10.1016/j.mehy.2014.06.004. Epub 2014 Jun 13.
10
[Hemorrhagic cystitis caused by BK and JC polyomavirus in patients treated with bone marrow transplantation: clinical features and urologic management].[骨髓移植患者中由BK和JC多瘤病毒引起的出血性膀胱炎：临床特征及泌尿外科处理]
Actas Urol Esp. 2002 Feb;26(2):104-10. doi: 10.1016/s0210-4806(02)72741-1.

本文引用的文献

1
Concurrent BK polyomavirus, adenovirus and cytomegalovirus infections in a patient treated for chronic lymphocytic leukaemia.慢性淋巴细胞白血病患者在治疗过程中并发 BK 多瘤病毒、腺病毒和巨细胞病毒感染。
BMJ Case Rep. 2021 Jan 5;14(1):e235981. doi: 10.1136/bcr-2020-235981.
2
Isolation of a novel intertypic recombinant human mastadenovirus B2 from two unrelated bone marrow transplant recipients.从两名无亲缘关系的骨髓移植受者中分离出一种新型的人B2型腺病毒种间重组体。
New Microbes New Infect. 2020 Apr 9;35:100677. doi: 10.1016/j.nmni.2020.100677. eCollection 2020 May.
3
Co-infection with human polyomavirus BK enhances gene expression and replication of human adenovirus.人多瘤病毒BK的合并感染增强了人腺病毒的基因表达和复制。
Arch Virol. 2018 Jul;163(7):1841-1849. doi: 10.1007/s00705-018-3810-1. Epub 2018 Mar 26.
4
Late presentation of adenovirus-induced hemorrhagic cystitis and ureteral obstruction in a kidney-pancreas transplant recipient.肾胰移植受者中腺病毒诱导的出血性膀胱炎和输尿管梗阻的延迟表现
Proc (Bayl Univ Med Cent). 2015 Oct;28(4):488-91. doi: 10.1080/08998280.2015.11929318.
5
Mechanisms of hemorrhagic cystitis.出血性膀胱炎的机制
Am J Clin Exp Urol. 2014 Oct 2;2(3):199-208. eCollection 2014.
6
Hospital admissions following outpatient administration of high-dose melphalan and autologous SCT for AL amyloidosis.门诊给予大剂量美法仑及自体干细胞移植治疗AL淀粉样变性后的住院情况。
Bone Marrow Transplant. 2014 Oct;49(10):1345-6. doi: 10.1038/bmt.2014.132. Epub 2014 Jun 23.
7
Prevalence of viral infections and hemorrhagic cystitis in hematopoietic stem cell transplant recipients.造血干细胞移植受者中病毒感染和出血性膀胱炎的患病率。
Exp Clin Transplant. 2011 Dec;9(6):405-12.
8
Hemorrhagic cystitis: A challenge to the urologist.出血性膀胱炎：对泌尿外科医生的一项挑战。
Indian J Urol. 2010 Apr;26(2):159-66. doi: 10.4103/0970-1591.65380.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验