Reusch R N
Chem Phys Lipids. 1985 Apr;37(1):53-67. doi: 10.1016/0009-3084(85)90074-x.
The ionophoretic capabilities of phosphoglycerides (PL) have been examined by measuring their translocation via cations from aqueous dispersions into linear and cyclic hydrocarbons. The PL surveyed were phosphatidic acid (PA), phosphatidylglycerol (PG), phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylinositol (PI). Only PA displayed ionophoretic activity in single lipid dispersions with a cation selectivity order of Mn greater than Ca. PG, PE and PC, but not PI, had a synergistic affect of PA induced translocation. These PL, inactive individually or in any combination, became strong Ca2+ ionophores of variable activity in association with PA. A dimeric structure proposed for the ionophoretic species forms the basis of a mechanism for transbilayer movement of PA, PG, PE and PC which would establish an asymmetric distribution of these lipids in the two faces of the bilayer by equilibrium processes.
通过测量磷脂（PL）经由阳离子从水分散体转运至直链和环状烃中的情况，对其离子载体能力进行了研究。所研究的磷脂包括磷脂酸（PA）、磷脂酰甘油（PG）、磷脂酰乙醇胺（PE）、磷脂酰胆碱（PC）和磷脂酰肌醇（PI）。在单一脂质分散体中，只有PA表现出离子载体活性，阳离子选择性顺序为Mn大于Ca。PG、PE和PC（但不包括PI）对PA诱导的转运具有协同作用。这些单独或任意组合时均无活性的磷脂，与PA结合后成为活性可变的强Ca2+离子载体。为离子载体物种提出的二聚体结构构成了PA、PG、PE和PC跨双层移动机制的基础，该机制将通过平衡过程在双层的两个面中建立这些脂质的不对称分布。
