National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
J Integr Plant Biol. 2018 Sep;60(9):851-863. doi: 10.1111/jipb.12655. Epub 2018 Jul 9.
Phospholipids, including phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidylserine (PS) and phosphoinositides, have emerged as an important class of cellular messenger molecules in various cellular and physiological processes, of which PA attracts much attention of researchers. In addition to its effect on stimulating vesicle trafficking, many studies have demonstrated that PA plays a crucial role in various signaling pathways by binding target proteins and regulating their activity and subcellular localization. Here, we summarize the functional mechanisms and target proteins underlying PA-mediated regulation of cellular signaling, development, hormonal responses, and stress responses in plants.
磷脂，包括磷脂酸（PA）、磷脂酰胆碱（PC）、磷脂酰乙醇胺（PE）、磷脂酰甘油（PG）、磷脂酰丝氨酸（PS）和磷酸肌醇，已成为各种细胞和生理过程中一类重要的细胞信使分子，其中 PA 引起了研究人员的广泛关注。除了刺激囊泡运输的作用外，许多研究表明 PA 通过与靶蛋白结合并调节其活性和亚细胞定位，在各种信号通路中发挥关键作用。在这里，我们总结了 PA 介导的植物细胞信号转导、发育、激素反应和应激反应的功能机制和靶蛋白。
