Canuto R A, Biocca M E, Muzio G, Garcea R, Dianzani M U
Cell Biochem Funct. 1985 Jan;3(1):3-8. doi: 10.1002/cbf.290030103.
Some aldehydes, produced during lipid peroxidation of liver lipids, are able to inhibit the respiration of mitochondria and of intact cells both in normal hepatocytes and in Yoshida hepatoma. In mitochondria, the respiratory stimulation produced by addition of ADP and dinitrophenol is decreased more in hepatoma than in normal liver. Two- to four-fold higher concentrations of aldehydes are needed to obtain the same degree of inhibition in normal liver mitochondria as in tumorous organs. The effect of aldehydes on intact cell respiration is absent or very low in hepatocytes, but it is consistently observed in hepatoma cells.
在肝脏脂质过氧化过程中产生的一些醛类物质，能够抑制正常肝细胞和吉田肝癌细胞中线粒体及完整细胞的呼吸作用。在肝癌细胞的线粒体中，添加二磷酸腺苷（ADP）和二硝基苯酚所产生的呼吸刺激作用，相较于正常肝脏细胞，其减弱程度更大。与肿瘤器官相比，需要两到四倍更高浓度的醛类物质才能在正常肝脏线粒体中达到相同程度的抑制效果。醛类物质对正常肝细胞完整细胞呼吸作用的影响不存在或非常低，但在肝癌细胞中却始终可以观察到这种影响。
