["In vitro" stimulation of TBArs. Production by carbon tetrachloride in MH1C1 hepatoma (author's transl)].

It is well known that lipid peroxidation is absent or extremely low in tumour tissues. So the lack of lipid peroxidation is so far considered as a peculiar characteristic of tumour cells. Studying lipid peroxidation in three different hepatomas, we have found, however, results suggesting that the lack of lipid peroxidation cannot be retained anymore as a constant attribute of hepatoma cells. In fact, we studied the TBArs production in homogenates of the following hepatomas: AH-130 Yoshida , 3924 A Morris, MH1C1 hepatomas, in comparison with normal liver. Whereas we were able to confirm that TBArs production in Yoshida tumour is extremely low, we found that Morris 3924 A hepatoma, growing subcutaneously in the rat, displays a rather consistent TBArs production. Moreover, MH1C1 hepatoma, grown in cell culture, produces more TBArs than normal liver. AH-130 Yoshida tumour is unable to metabolize CC14. Consequently, the addition of CC14 to the homogenate doesn't stimulate TBArs production, as this substances does in the case of normal liver homogenate. A good increase in TBArs production was seen, however, with MH1C1 homogenate.