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评估.提取物对哈杰省三级医院医疗相关感染的抗菌潜力：一项 研究。 （你提供的原文中存在信息不完整的情况，比如Extract前有内容缺失，Study前也有内容缺失）

Evaluating Anti- Potential of . Extract against Healthcare-Associated Infections in Tertiary Hospitals of Al-Kharj Governorate: An Study.

作者信息

Khan Mohammed S, Bari Md Nadeem

机构信息

Department of Basic Medical Sciences, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.

出版信息

J Pharm Bioallied Sci. 2024 Dec;16(Suppl 5):S4649-S4654. doi: 10.4103/jpbs.jpbs_1253_24. Epub 2025 Jan 30.

DOI:10.4103/jpbs.jpbs_1253_24
PMID:40061695
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11888659/
Abstract

BACKGROUND

Healthcare-associated infections (HAIs) caused by pathogens are a significant concern in tertiary hospitals worldwide, including those in Al-Kharj, Saudi Arabia. This study aimed to explore the bioactive compounds from and evaluate their antimicrobial activity against pathogens.

MATERIALS AND METHODS

Methanolic extracts of the stem were prepared and subjected to phytochemical analysis, thin-layer chromatography (TLC), and antimicrobial testing using the well-diffusion method. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and cytotoxicity (MTT assay) were also evaluated.

RESULTS

The extract contained several major phytochemicals with significant activity against pathogens. The MIC values were 50 mg/mL for , , and , 100 mg/mL for and , and 25 mg/mL for . The MBC values were 25 mg/mL for and 100 mg/mL for the other pathogens.

CONCLUSION

The methanolic extract of . demonstrated potent antimicrobial activity, with relatively low MIC and MBC values against pathogens responsible for HAIs.

摘要

背景

由病原体引起的医疗保健相关感染（HAIs）是全球三级医院（包括沙特阿拉伯哈杰的医院）的一个重大问题。本研究旨在探索[植物名称]的生物活性化合物，并评估其对病原体的抗菌活性。

材料与方法

制备[植物名称]茎的甲醇提取物，并进行植物化学分析、薄层色谱（TLC）以及采用打孔扩散法进行抗菌测试。还评估了最低抑菌浓度（MIC）、最低杀菌浓度（MBC）和细胞毒性（MTT 法）。

结果

提取物含有几种对病原体具有显著活性的主要植物化学物质。[具体病原体1]、[具体病原体2]和[具体病原体3]的 MIC 值为 50 mg/mL，[具体病原体4]和[具体病原体5]的 MIC 值为 100 mg/mL，[具体病原体6]的 MIC 值为 25 mg/mL。[具体病原体1]的 MBC 值为 25 mg/mL，其他病原体的 MBC 值为 100 mg/mL。

结论

[植物名称]的甲醇提取物表现出强大的抗菌活性，对导致 HAIs 的病原体具有相对较低的 MIC 和 MBC 值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/fa8760e66d73/JPBS-16-4649-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/b081c0dfc9e3/JPBS-16-4649-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/fe41f7cec571/JPBS-16-4649-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/d18a047d9e4e/JPBS-16-4649-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/b2410a40004e/JPBS-16-4649-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/34073e553f9f/JPBS-16-4649-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/fa8760e66d73/JPBS-16-4649-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/b081c0dfc9e3/JPBS-16-4649-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/fe41f7cec571/JPBS-16-4649-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/d18a047d9e4e/JPBS-16-4649-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/b2410a40004e/JPBS-16-4649-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/34073e553f9f/JPBS-16-4649-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e7/11888659/fa8760e66d73/JPBS-16-4649-g006.jpg

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2
National Healthcare-Associated Infections Report 2022 - Saudi Arabia.《2022年沙特阿拉伯国家医疗相关感染报告》
J Infect Public Health. 2023 Nov;16(11):1769-1772. doi: 10.1016/j.jiph.2023.07.007. Epub 2023 Jul 26.
3
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Microbiol Spectr. 2023 Jun 15;11(3):e0028023. doi: 10.1128/spectrum.00280-23. Epub 2023 Apr 20.
4
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Vegetos. 2023 Jan 18:1-11. doi: 10.1007/s42535-022-00549-2.
5
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8
The potential of as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry.作为一种中药的潜力：传统临床应用、生物活性及植物化学。
Front Pharmacol. 2022 Sep 21;13:973138. doi: 10.3389/fphar.2022.973138. eCollection 2022.
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