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诃子通过HS信号通路对脂多糖诱导的RAW巨噬细胞的保护作用

Protective Effect of Triphala Mediated by HS Signaling Pathway in LPS-Induced RAW Macrophages.

作者信息

Shanker Shyam Sundar, Dasgupta Tiasha, Hussain Sharmila, Annapoorni H, Tamizhselvi Ramasamy

机构信息

Department of Prosthodontics Crown and Bridge, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Tamil Nadu, India.

Department of Biosciences, School of Bioscience and Technology, Vellore Institute of Technology, Tamil Nadu, India.

出版信息

J Pharm Bioallied Sci. 2024 Dec;16(Suppl 5):S4511-S4513. doi: 10.4103/jpbs.jpbs_1059_24. Epub 2025 Jan 30.

DOI:10.4103/jpbs.jpbs_1059_24
PMID:40061697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11888769/
Abstract

INTRODUCTION

MacrophagesHydrogen sulfide (H2 S), an endogenously produced gasotransmitter, is a wellknown inflammatory agent production successfully controlled with triphala in macrophages.

MATERIALS AND METHOD

The ELISA analysis revealed that triphala extracts suppress the protein expression of NFκB (p65) and downregulation of the CSE gene expression. Moreover, in the presence of propargylglycine (PAG) the expression of NFκB and CSE gene was further reduced.

RESULTS

These results suggest that triphala could be a potent antiinflammatory effect that could be used for the treatment of many inflammatory disorders, including periimplantitis.

摘要

引言

巨噬细胞

硫化氢（H₂S）是一种内源性产生的气体信号分子，是一种众所周知的炎症介质，在巨噬细胞中，三果（triphala）能成功控制其产生。

材料与方法

酶联免疫吸附测定（ELISA）分析表明，三果提取物可抑制核因子κB（NFκB，p65）的蛋白表达，并下调胱硫醚γ-裂解酶（CSE）基因的表达。此外，在炔丙基甘氨酸（PAG）存在的情况下，NFκB和CSE基因的表达进一步降低。

结果

这些结果表明，三果可能具有强大的抗炎作用，可用于治疗包括种植体周炎在内的多种炎症性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf8/11888769/f0cf8befd7b7/JPBS-16-4511-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf8/11888769/04058be8e878/JPBS-16-4511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf8/11888769/765818d2e63f/JPBS-16-4511-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf8/11888769/f0cf8befd7b7/JPBS-16-4511-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf8/11888769/04058be8e878/JPBS-16-4511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf8/11888769/765818d2e63f/JPBS-16-4511-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf8/11888769/f0cf8befd7b7/JPBS-16-4511-g003.jpg

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本文引用的文献

1
Hydrogen sulfide: An endogenous regulator of the immune system.硫化氢：免疫系统的内源性调节剂。
Pharmacol Res. 2020 Nov;161:105119. doi: 10.1016/j.phrs.2020.105119. Epub 2020 Aug 8.
2
Expression and activity of hydrogen sulfide generating enzymes in murine macrophages stimulated with lipopolysaccharide and interferon-γ.脂多糖和干扰素-γ刺激的小鼠巨噬细胞中硫化氢生成酶的表达和活性。
Mol Biol Rep. 2019 Jun;46(3):2791-2798. doi: 10.1007/s11033-019-04725-7. Epub 2019 Mar 11.
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NF-κB signaling in inflammation.NF-κB 信号转导与炎症
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The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages.硫化氢供体对脂多糖诱导的巨噬细胞中炎症介质形成的影响。
Antioxid Redox Signal. 2010 May 15;12(10):1147-54. doi: 10.1089/ars.2009.2899.