Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA.
Signal Transduct Target Ther. 2017;2:17023-. doi: 10.1038/sigtrans.2017.23. Epub 2017 Jul 14.
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells. Consequently, deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-κB inhibition.
转录因子 NF-κB 调节先天和适应性免疫功能的多个方面，是炎症反应的关键介质。NF-κB 诱导多种促炎基因的表达，包括细胞因子和趋化因子的编码基因，并且还参与炎症小体的调节。此外，NF-κB 在调节先天免疫细胞和炎症性 T 细胞的存活、激活和分化方面起着关键作用。因此，NF-κB 激活的失调导致各种炎症性疾病的发病过程。在这篇综述中，我们将讨论 NF-κB 的激活和功能与炎症性疾病的关系，并强调基于 NF-κB 抑制的治疗策略的发展。
