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术后胃肠手术患者免疫功能恢复的个性化营养护理:一项观察性研究。

Personalized nutritional care for immune function recovery in postoperative gastrointestinal surgery patients: An observational study.

作者信息

Zhong Fang-Hong

机构信息

Department of Clinical Nutrition, Ganzhou People's Hospital, Ganzhou 341000, Jiangxi Province, China.

出版信息

World J Gastrointest Surg. 2025 Feb 27;17(2):99893. doi: 10.4240/wjgs.v17.i2.99893.

Abstract

BACKGROUND

Gastrointestinal (GI) surgery can significantly affect the nutritional status and immune function of patients. This study aimed to investigate the effects of personalized nutritional care on the recovery of immune function in patients who underwent postoperative GI surgery.

AIM

To study examines personalized nutritional care's impact on immune function recovery, nutritional status, and clinical outcomes after GI surgery.

METHODS

This observational study included 80 patients who underwent GI surgery between 2021 and 2023. Patients received personalized nutritional care based on their individual needs and surgical outcomes. Immune function markers including lymphocyte subsets, immunoglobulins, and cytokines were measured preoperatively and at regular intervals postoperatively. Nutritional status, clinical outcomes, and quality of life were assessed.

RESULTS

Patients receiving personalized nutritional care showed significant improvements in immune function markers compared to baseline. At 4 weeks postoperatively, CD4+ T-cell counts increased by 25% ( < 0.001), while interleukin-6 levels decreased by 40% ( < 0.001). Nutritional status, as measured by prealbumin and transferrin levels, improved by 30% ( < 0.01). Postoperative complications reduced by 35% compared to historical controls. The quality-of-life scores improved by 40% at 3 months postoperatively.

CONCLUSION

Personalized nutritional care enhances immune function recovery, improves nutritional status, and reduces complications in patients undergoing postoperative GI surgery, highlighting its crucial role in optimizing patient outcomes following such procedures.

摘要

背景

胃肠道(GI)手术会显著影响患者的营养状况和免疫功能。本研究旨在探讨个性化营养护理对接受胃肠道手术后患者免疫功能恢复的影响。

目的

研究个性化营养护理对胃肠道手术后免疫功能恢复、营养状况及临床结局的影响。

方法

本观察性研究纳入了2021年至2023年间接受胃肠道手术的80例患者。患者根据其个体需求和手术结果接受个性化营养护理。术前及术后定期测量免疫功能指标,包括淋巴细胞亚群、免疫球蛋白和细胞因子。评估营养状况、临床结局和生活质量。

结果

与基线相比,接受个性化营养护理的患者免疫功能指标有显著改善。术后4周,CD4 + T细胞计数增加了25%(P < 0.001),而白细胞介素-6水平下降了40%(P < 0.001)。以前白蛋白和转铁蛋白水平衡量的营养状况改善了30%(P < 0.01)。与历史对照组相比,术后并发症减少了35%。术后3个月时生活质量评分提高了40%。

结论

个性化营养护理可促进接受胃肠道手术后患者的免疫功能恢复,改善营养状况,并减少并发症,凸显了其在此类手术优化患者结局方面的关键作用。

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