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免疫功能正常女孩中诊断出的传染性软疣感染的带状疱疹样播散:一种罕见的临床表现。

Zosteriform Dissemination of Molluscum Contagiosum Infection Diagnosed in an Immunocompetent Girl: A Rare Clinical Presentation.

作者信息

Marashli Aya, Adi Mohammad, Al-Shehabi Zuheir, Al-Soufi Lina

机构信息

Department of Dermatology National Hospital Latakia Syria.

Faculty of Medicine Damascus University Damascus Syria.

出版信息

Clin Case Rep. 2025 Mar 7;13(3):e70301. doi: 10.1002/ccr3.70301. eCollection 2025 Mar.

DOI:10.1002/ccr3.70301
PMID:40062313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11888931/
Abstract

Molluscum contagiosum (MC) is a benign, self-limiting infectious lesion that primarily affects children and young adults, especially those with immunodeficiency. MC is caused by a poxvirus from the Molluscipoxvirus genus of the Poxviridae family. Diagnosis is mainly clinical, with lesions presenting as dome-shaped, spherical, solid, flesh-colored, pearly papules with central umbilication. MC commonly appears on the limbs, face, trunk, and axillary regions. The differential diagnosis includes inflammatory, infectious, and neoplastic causes, varying by age and immunological condition. This case report presents a rare zosteriform distribution of MC infection in an immunocompetent girl, a presentation described only twice in medical literature. The unusual distribution resulted from scratching, a process known as the Koebner phenomenon (pseudo-koebnerization).

摘要

传染性软疣(MC)是一种良性、自限性感染性损害,主要影响儿童和年轻人,尤其是免疫功能低下者。MC由痘病毒科软疣痘病毒属的一种痘病毒引起。诊断主要依靠临床症状,皮损表现为圆顶形、球形、坚实、肤色、珍珠样丘疹,中央有脐凹。MC常见于四肢、面部、躯干和腋窝部位。鉴别诊断包括炎症性、感染性和肿瘤性病因,因年龄和免疫状况而异。本病例报告呈现了一名免疫功能正常女孩罕见的带状疱疹样分布的MC感染,这种表现仅在医学文献中被描述过两次。这种不寻常的分布是由搔抓引起的,这一过程称为同形反应(假同形反应)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9e/11888931/3ebeae4d5925/CCR3-13-e70301-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9e/11888931/247be87c6697/CCR3-13-e70301-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9e/11888931/3ebeae4d5925/CCR3-13-e70301-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9e/11888931/247be87c6697/CCR3-13-e70301-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9e/11888931/3ebeae4d5925/CCR3-13-e70301-g002.jpg

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本文引用的文献

1
Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment.传染性软疣:病因、诊断及治疗新视角的最新进展与综述
Clin Cosmet Investig Dermatol. 2019 May 30;12:373-381. doi: 10.2147/CCID.S187224. eCollection 2019.
2
Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells.糖皮质激素对T细胞和炎症细胞的调节及作用机制
Front Endocrinol (Lausanne). 2018 May 16;9:235. doi: 10.3389/fendo.2018.00235. eCollection 2018.
3
Molluscum Contagiosum: An Update.传染性软疣:最新进展
Recent Pat Inflamm Allergy Drug Discov. 2017;11(1):22-31. doi: 10.2174/1872213X11666170518114456.