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结核病和非结核分枝杆菌病年度回顾:2025年临床医生和科学家最新进展

A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2025 Update for Clinicians and Scientists.

作者信息

Lange Christoph, Bothamley Graham, Günther Gunar, Guglielmetti Lorenzo, Kontsevaya Irina, Kuksa Liga, Lange Berit, Lorent Natalie, Saluzzo Francesca, Sester Martina, Tebruegge Marc, Tunesi Simone, Tweed Conor

机构信息

Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Clinical Tuberculosis Unit, German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Germany.

出版信息

Pathog Immun. 2025 Mar 2;10(2):1-45. doi: 10.20411/pai.v10i2.791. eCollection 2025.

DOI:10.20411/pai.v10i2.791
PMID:40062355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11888605/
Abstract

BACKGROUND

In the field of tuberculosis and non-tuberculous mycobacterial (NTM) disease we are looking back on an exciting year 2024 with more than 10,000 publications listed in PubMed.

METHODS

Our aim, to review the scientific literature of the year 2024, is challenged by the enormous number of publications. Therefore, if your article is not included or your favorite field of mycobacteriology not covered, please forgive us. Our "Year in Review" is very much clinically oriented with lesser emphasis on basic science, microbiology, and biotechnology.

RESULTS

Members of the steering committee of the Tuberculosis Network European Trials group (TBnet; www.tbnet.eu) report on 139 publications in the fields of epidemiology, prevention, diagnosis, and treatment of tuberculosis and NTM diseases published in 2024 that we found particularly important. We report publications separately for tuberculosis in children and adults and for NTM disease and provide a brief overview of newer technologies in the diagnostic pipeline. Furthermore, we summarize priorities for tuberculosis and NTM disease research, development, and implementation, all of which represent the perspective of our combined clinical experience.

CONCLUSIONS

This Year in Review provides a concise summary of the clinically relevant highlights of the published literature in tuberculosis and NTM diseases in 2024.

摘要

背景

在结核病和非结核分枝杆菌(NTM)疾病领域,回顾2024年是令人兴奋的一年,PubMed上列出的相关出版物超过10000篇。

方法

我们旨在回顾2024年的科学文献,但面临着出版物数量众多的挑战。因此,如果您的文章未被纳入,或者您喜爱的分枝杆菌学领域未被涵盖,请原谅我们。我们的“年度回顾”非常注重临床,对基础科学、微生物学和生物技术的关注较少。

结果

欧洲结核病网络试验组(TBnet;www.tbnet.eu)指导委员会的成员报告了2024年发表的139篇在结核病和NTM疾病的流行病学、预防、诊断和治疗领域的出版物,我们认为这些尤为重要。我们分别报告了儿童和成人结核病以及NTM疾病的出版物,并简要概述了诊断流程中的新技术。此外,我们总结了结核病和NTM疾病研究、开发和实施的重点,所有这些都代表了我们综合临床经验的观点。

结论

本年度回顾简要总结了2024年发表的结核病和NTM疾病文献中与临床相关的要点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b60/11888605/8a969d222bdf/pai-10-001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b60/11888605/52600a14789f/pai-10-001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b60/11888605/8a969d222bdf/pai-10-001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b60/11888605/52600a14789f/pai-10-001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b60/11888605/8a969d222bdf/pai-10-001-g002.jpg

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High-sensitivity detection of DNA in tongue swab samples.舌拭子样本中DNA的高灵敏度检测。
J Clin Microbiol. 2025 Feb 19;63(2):e0114024. doi: 10.1128/jcm.01140-24. Epub 2024 Dec 31.
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The molecular bacterial load assay predicts treatment responses in patients with pre-XDR/XDR-tuberculosis more accurately than GeneXpert Ultra MTB/Rif.
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J Infect. 2025 Feb;90(2):106399. doi: 10.1016/j.jinf.2024.106399. Epub 2024 Dec 27.
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Effectiveness of the primary Bacillus Calmette-Guérin vaccine against the risk of Mycobacterium tuberculosis infection and tuberculosis disease: a meta-analysis of individual participant data.卡介苗初种疫苗预防结核分枝杆菌感染和结核病风险的有效性:个体参与者数据的荟萃分析
Lancet Microbe. 2025 Feb;6(2):100961. doi: 10.1016/j.lanmic.2024.100961. Epub 2024 Dec 19.
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A Meta-Analysis of Levofloxacin for Contacts of Multidrug-Resistant Tuberculosis.左氧氟沙星用于耐多药结核病接触者的荟萃分析。
NEJM Evid. 2025 Jan;4(1):EVIDoa2400190. doi: 10.1056/EVIDoa2400190. Epub 2024 Dec 18.
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Levofloxacin Preventive Treatment in Children Exposed to MDR Tuberculosis.左氧氟沙星对接触耐多药结核病儿童的预防性治疗
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