Jasim Saade Abdalkareem, Abdulrazzaq Sumaya Ayad, Malathi H, Iqbal Suhaib, Sanghvi Gaurav, Yulchiev E, Ray Subhashree, Sunitha S, Ahmed Jawad Kadhim, Zwamel Ahmed Hussein
Medical Laboratory Techniques Department, Al-Maarif University College, Anbar, Iraq.
Center of Desert Studies, University of Anbar, Anbar, Iraq.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 10. doi: 10.1007/s00210-025-03966-7.
Gastric cancer (GC) is the result of a convoluted series of incidents that include host genetic susceptibility, Helicobacter pylori infection, and other external influences. The emergence of many hereditary and chromatin modifications in carcinogenic and tumor-inhibiting genes results in the disruption of several molecular networks, upsetting the balance between cell proliferation and apoptosis as well as the cell cycle. Important roles are played by members of the Toll-like receptor (TLR) family in both native and adaptive immunological reactions. The owner can identify various pathogen-associated molecular patterns (PAMPs) with the TLR proteins, including DNA carrying CPG, viral RNA, and bacterial lipopolysaccharides. Moreover, the TLRs detect molecular patterns associated with danger, which have been connected to a number GC. According to different concepts, TLRs are expressed by both immunological and malignant cells. The several roles that TLRs play in GC were compiled in this review paper.
胃癌（GC）是一系列复杂事件的结果，这些事件包括宿主遗传易感性、幽门螺杆菌感染和其他外部影响。致癌基因和抑癌基因中许多遗传和染色质修饰的出现导致多个分子网络的破坏，扰乱了细胞增殖与凋亡以及细胞周期之间的平衡。Toll样受体（TLR）家族成员在天然免疫和适应性免疫反应中均发挥重要作用。宿主可通过TLR蛋白识别各种病原体相关分子模式（PAMP），包括携带胞嘧啶-磷酸-鸟嘌呤（CPG）的DNA、病毒RNA和细菌脂多糖。此外，TLR可检测与危险相关的分子模式，这些模式与多种胃癌相关。根据不同的概念，免疫细胞和恶性细胞均可表达TLR。本文综述了TLR在胃癌中所起的多种作用。
