Ruutu Katri, Wasenius Niko S, Narasimhan Kothandaraman, Mikkola Tuija M, Laine Merja K, Eriksson Johan G
Folkhälsan Research Center, Helsinki, Finland.
Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Aging Cell. 2025 Jun;24(6):e70033. doi: 10.1111/acel.70033. Epub 2025 Mar 10.
Physical activity (PA) may delay the onset of age-related diseases by decelerating biological aging. We investigated the association between leisure-time physical activity (LTPA) and metabolomics-based aging markers (MetaboAge and MetaboHealth) in late midlife and during 16 years of follow-up. At the 16-year follow-up, we also investigated the association between device-based PA and MetaboAge and MetaboHealth. We included 1816 individuals (mean age 61.6 years) from the Helsinki Birth Cohort Study at baseline and followed them up for 5 (n = 982) and 16 years (n = 744), respectively. LTPA was assessed via questionnaire at baseline and 16 years later and device-based PA with ActiGraph accelerometer at the 16-year follow-up. Fasting blood samples were applied to calculate MetaboAge acceleration (ΔmetaboAge) and MetaboHealth at baseline and at both follow-ups. Covariate-adjusted multiple regression analyses and linear mixed models were applied to study the associations. A higher volume of LTPA at baseline was associated with a lower MetaboHealth score at the 5-year follow-up (p < 0.0001 for time × LTPA interaction). No associations were detected at the 16-year follow-up. An increase in LTPA over 16 years was associated with a decrease in MetaboHealth score (p < 0.001) and a decrease in LTPA with an increase in MetaboHealth score. Higher device-based PA was associated with a lower MetaboHealth score, but not with ΔmetaboAge. In conclusion, higher LTPA in late midlife and device-based PA in old age were associated with improved MetaboHealth. Increasing LTPA with age may protect against MetaboHealth-based aging. The results support the importance of PA for biological aging in later life.
身体活动（PA）可能通过减缓生物衰老来延迟与年龄相关疾病的发生。我们调查了中年后期及16年随访期间休闲时间身体活动（LTPA）与基于代谢组学的衰老标志物（代谢年龄和代谢健康）之间的关联。在16年随访时，我们还调查了基于设备的身体活动与代谢年龄和代谢健康之间的关联。我们纳入了赫尔辛基出生队列研究中1816名基线时的个体（平均年龄61.6岁），并分别对他们进行了5年（n = 982）和16年（n = 744）的随访。LTPA在基线和16年后通过问卷进行评估，基于设备的身体活动在16年随访时使用ActiGraph加速度计进行评估。在基线和两次随访时，采集空腹血样以计算代谢年龄加速（Δ代谢年龄）和代谢健康。采用协变量调整的多元回归分析和线性混合模型来研究这些关联。基线时较高的LTPA量与5年随访时较低的代谢健康评分相关（时间×LTPA交互作用的p < 0.0001）。在16年随访时未检测到关联。16年间LTPA的增加与代谢健康评分的降低相关（p < 0.001），而LTPA的减少与代谢健康评分的增加相关。较高的基于设备的身体活动与较低的代谢健康评分相关，但与Δ代谢年龄无关。总之，中年后期较高的LTPA和老年时基于设备的身体活动与改善的代谢健康相关。随着年龄增长增加LTPA可能预防基于代谢健康的衰老。结果支持身体活动对晚年生物衰老的重要性。
