Bravo-Garcia Ana Paula, Radford Bridget E, Hall Rebecca C, Broome Sophie C, Tee Nicolin, Arthur Bronte, Janssens Kristel, Johnston Rich D, Halson Shona L, Devlin Brooke L, Hawley John A, Parr Evelyn B
Mary MacKillop Institute for Health Research, Australian Catholic University (ACU), Australia.
Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Melbourne, Australia; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Queensland, Australia; Carnegie Applied Rugby Research (CARR) Centre, Carnegie School of Sport, Leeds Beckett University, United Kingdom.
Diabetes Res Clin Pract. 2025 Apr;222:112081. doi: 10.1016/j.diabres.2025.112081. Epub 2025 Mar 8.
Time-restricted eating (TRE) is a chrono-nutrition strategy where the daily 'eating window' is reduced to 8-10 h. We investigated the acute (14-h) effects of TRE, with and without post-meal exercise, on blood glucose and insulin concentrations in people with type 2 diabetes mellitus.
Fourteen participants (5 F, 9 M; HbA1c: 7.6 ± 1.0%) completed four conditions in this randomised crossover study: CON (eating window, 0800-2000 h), CON with exercise (CON + Ex; 0800-2000 h + 15 min walking at 60% VOpeak, 45 min post-meal), TRE (eating window 1000-1800 h), and TRE with exercise (TRE + Ex, 1000-1800 h + 15 min walking as per CON + Ex), with standardised meals. Venous blood samples were collected at 26-timepoints and analysed for glucose and insulin concentrations. Statistical analysis used linear mixed-effects models with P < 0.05.
Reducing the eating window had little effect on plasma glucose 14-h area under the curve (AUC). Exercise reduced insulin 14-h AUC (P=0.01) with no additive effect of TRE.
Post-meal exercise lowered 14-h insulin AUC, neither 8-h TRE nor post-meal exercise altered 14-h blood glucose compared with 12-h eating window. Future work should focus on long-term effects of TRE combined with exercise for enhancing blood glucose in people with type 2 diabetes mellitus.
限时进食（TRE）是一种时间营养学策略，即将每日的“进食窗口”缩短至8 - 10小时。我们研究了限时进食在有或没有餐后运动的情况下，对2型糖尿病患者血糖和胰岛素浓度的急性（14小时）影响。
14名参与者（5名女性，9名男性；糖化血红蛋白：7.6 ± 1.0%）在这项随机交叉研究中完成了四种情况：对照组（进食窗口，08:00 - 20:00），运动对照组（对照组 + 运动；08:00 - 20:00 + 餐后45分钟以60%峰值摄氧量进行15分钟步行），限时进食组（进食窗口10:00 - 18:00），以及运动限时进食组（限时进食 + 运动，10:00 - 18:00 + 同运动对照组的15分钟步行），均提供标准化餐食。在26个时间点采集静脉血样，并分析血糖和胰岛素浓度。统计分析采用线性混合效应模型，P < 0.05。
缩短进食窗口对血浆葡萄糖曲线下14小时面积（AUC）影响不大。运动降低了胰岛素14小时AUC（P = 0.01），限时进食没有叠加效应。
餐后运动降低了14小时胰岛素AUC，与12小时进食窗口相比，8小时限时进食和餐后运动均未改变14小时血糖。未来的研究应聚焦于限时进食与运动相结合对改善2型糖尿病患者血糖的长期影响。
