Baghaie Hooman, Shukla Khilan, Stone Jennifer, Breik Omar, Munn Zachary
JBI, School of Public Health, The University of Adelaide, Adelaide, SA, Australia.
School of Medicine, Griffith University, Brisbane, QLD, Australia.
Aesthetic Plast Surg. 2025 Mar 10. doi: 10.1007/s00266-025-04738-7.
The objective of this systematic review and meta-analysis was to assess the effects of tranexamic acid (TXA) on bleeding and thromboembolic events in orthognathic surgery out.
Three electronic databases (PubMed, Web of Science, and Cochrane Library) were searched until 01/06/2024.
Nine randomised controlled trials and two cohort studies were included for pooled analysis. Compared with the control group, the TXA group showed a mean reduction in intraoperative blood loss of 171.30 ml (p < 0.00001; 95% CI, 197.58-145.02 ml). Systemic tranexamic acid use was associated with reduced operative time by a mean of14.5 minutes (p < 0.0001; 95% CI, 20.89-8.02 mins) and reduction in the need for transfusion OR= 0.33 (p < 0.01; 95% CI, 0.14-0.77).
This systematic review and meta-analysis supports the prophylactic use of tranexamic acid during orthognathic surgery in reducing blood loss, operative time and the risk of needing blood transfusions without increasing risk of thromboembolic complications.
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to Table of Contents or the online Instructions to Authors www.springer.com/00266 .
本系统评价和荟萃分析的目的是评估氨甲环酸（TXA）对正颌外科手术中出血和血栓栓塞事件的影响。
检索了三个电子数据库（PubMed、科学网和考克兰图书馆），直至2024年6月1日。
纳入九项随机对照试验和两项队列研究进行汇总分析。与对照组相比，TXA组术中失血量平均减少171.30毫升（p<0.00001；95%CI，197.58 - 145.02毫升）。全身使用氨甲环酸可使手术时间平均缩短14.5分钟（p<0.0001；95%CI，20.89 - 8.02分钟），输血需求减少，OR = 0.33（p<0.01；95%CI，0.14 - 0.77）。
本系统评价和荟萃分析支持在正颌外科手术中预防性使用氨甲环酸，以减少失血量、手术时间和输血风险，且不增加血栓栓塞并发症的风险。
证据等级I：本刊要求作者为每篇文章指定证据等级。有关这些循证医学评级的完整描述，请参阅目录或在线作者指南www.springer.com/00266 。
