Huang Shih-Wei, Chang Ko-Wei, Chen Wei-Hsun, Chou Pin-Li, Chiu Chien-Hung, Liu Yun-Hen, Wang Chih-Wei, Kao Hsiao-Wen, Lin Tung-Liang, Leu Shaw-Woei, Hu Han-Chung, Kao Kuo-Chin
Department of Thoracic Medicine Chang Gung Memorial Hospital Taoyuan Taiwan.
Graduate Institute of Clinical Medical Sciences, College of Medicine Chang Gung University Taoyuan Taiwan.
Respirol Case Rep. 2025 Mar 10;13(3):e70120. doi: 10.1002/rcr2.70120. eCollection 2025 Mar.
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for multiple myeloma; however, the development of chronic graft-versus-host disease remains a significant challenge. Bronchiolitis obliterans syndrome (BOS) is one of the complications. Even with available medications for treatment, the prognosis of BOS remains poor. We present a 32-year-old female with multiple myeloma experienced BOS 6 months after allo-HSCT. Even with medical treatment, her clinical condition and pulmonary function was deteriorating. Based on the indication of a BODE (Body-mass index, Obstruction, Dyspnoea and Exercise) index of 7, she underwent bilateral lung transplantation 33 months after allo-HSCT. Three months post-operation, there was a significant improvement in pulmonary function. After approximately 5 years of follow-up, her lung function remains stable, and she is able to work and live a normal life. Lung transplantation may be an effective therapeutic strategy for BOS developed after allo-HSCT.
异基因造血干细胞移植（allo-HSCT）是治疗多发性骨髓瘤的一种有效方法；然而，慢性移植物抗宿主病的发生仍然是一个重大挑战。闭塞性细支气管炎综合征（BOS）是其并发症之一。即使有可用的治疗药物，BOS的预后仍然很差。我们报告一名32岁的多发性骨髓瘤女性患者，在allo-HSCT后6个月出现了BOS。即使经过药物治疗，她的临床状况和肺功能仍在恶化。根据BODE（体重指数、阻塞、呼吸困难和运动能力）指数为7的指征，她在allo-HSCT后33个月接受了双侧肺移植。术后3个月，肺功能有显著改善。经过大约5年的随访，她的肺功能保持稳定，能够工作并过上正常生活。肺移植可能是allo-HSCT后发生BOS的一种有效治疗策略。
