Estrela Santos Mariana, Carmo Francisca, Miranda João, Moura Raquel, Resende Janine
Internal Medicine, Unidade Local de Saúde Gaia Espinho, Vila Nova de Gaia, PRT.
Cureus. 2025 Feb 8;17(2):e78735. doi: 10.7759/cureus.78735. eCollection 2025 Feb.
Ethanol-disulfiram reaction (EDR) is a rare but potentially life-threatening condition characterized by a constellation of symptoms, including flushing, hypotension, tachycardia, nausea, and vomiting. We report the case of a 52-year-old male patient who presented with acute hemodynamic instability after inadvertent alcohol consumption while on disulfiram therapy for alcohol dependence. The patient exhibited signs of shock, including hypotension and hyperlactatemia, but responded promptly to fluid resuscitation and transient vasopressor support. A detailed history confirmed the diagnosis of EDR. This case highlights the importance of recognizing EDR as a differential diagnosis in patients with acute hemodynamic instability and a relevant clinical history. Early identification and supportive management are crucial for favorable outcomes.
乙醇-双硫仑反应（EDR）是一种罕见但可能危及生命的病症，其特征为一系列症状，包括脸红、低血压、心动过速、恶心和呕吐。我们报告一例52岁男性患者，该患者在因酒精依赖接受双硫仑治疗期间意外饮酒后出现急性血流动力学不稳定。患者表现出休克迹象，包括低血压和高乳酸血症，但对液体复苏和短暂的血管加压药支持反应迅速。详细病史确诊为EDR。该病例强调了将EDR识别为急性血流动力学不稳定且有相关临床病史患者的鉴别诊断的重要性。早期识别和支持性管理对取得良好预后至关重要。
