Sharma V, Sharma A, Kumar V, Aggarwal S
Department of Medicine, University College of Medical Sciences & GTB Hospital, Delhi, India.
J Postgrad Med. 2009 Oct-Dec;55(4):292-3. doi: 10.4103/0022-3859.58940.
Many drugs are implicated in causation of disulfiram-like reaction. The disulfiram-like reaction can vary in severity and can occasionally be fatal. The reaction is believed to result from inhibition of metabolism of acetaldehyde to acetate by inhibition of aldehyde dehydrogenase. The increase in serum acetaldehyde results in unpleasant clinical manifestations. Metronidazole is known to cause disulfiram-like reaction. Although no previous report has implicated ornidazole in causation of disulfiram-like reaction, caution has been advised with the use of all imidazoles. We report the case of a 48-year-old male, who was taking ornidazole and developed features of disulfiram-like reaction after taking alcohol. The patient was managed with supportive measures and improved. The report highlights the need for clinicians to advise patients to restrict intake of alcohol if they are being prescribed imidazole derivatives.
许多药物都与双硫仑样反应的发生有关。双硫仑样反应的严重程度各不相同，偶尔甚至会致命。据信，该反应是由于醛脱氢酶受到抑制，从而抑制了乙醛代谢为乙酸所致。血清乙醛水平升高会导致出现令人不适的临床表现。已知甲硝唑会引起双硫仑样反应。尽管此前尚无报告表明奥硝唑会引发双硫仑样反应，但使用所有咪唑类药物时都建议谨慎。我们报告了一例48岁男性病例，该患者正在服用奥硝唑，饮酒后出现了双硫仑样反应的症状。患者接受了支持性治疗措施并有所好转。该报告强调，临床医生有必要告知患者，如果他们正在服用咪唑衍生物，应限制酒精摄入。
