Khanal Surendra, Rizvi Rameela, March Christopher
Internal Medicine, Piedmont Athens Regional, Athens, USA.
Cureus. 2025 Feb 7;17(2):e78665. doi: 10.7759/cureus.78665. eCollection 2025 Feb.
Nonsecretory multiple myeloma (NSMM) is the variant of multiple myeloma defined by no detectable M protein secretion in serum or urine electrophoresis. Due to the lack of detectable M spike, diagnosis is often challenging and relies on bone marrow studies. As studies specifically focusing on NSMM are lacking, the current treatment guidelines are based on studies in secretory multiple myeloma. In this case report, we describe a 77-year-old female patient with a typical presentation of NSMM who did not respond to a chemotherapy regimen based on daratumumab.
非分泌型多发性骨髓瘤（NSMM）是多发性骨髓瘤的一种变体，其定义为血清或尿液电泳中未检测到M蛋白分泌。由于缺乏可检测到的M峰，诊断往往具有挑战性，且依赖于骨髓检查。由于缺乏专门针对NSMM的研究，目前的治疗指南是基于分泌型多发性骨髓瘤的研究制定的。在本病例报告中，我们描述了一名77岁的女性患者，她具有NSMM的典型表现，对基于达雷妥尤单抗的化疗方案无反应。
