Yousefi Mohammad Hasan, Masoudi Alireza, Saberi Rounkian Masoumeh, Mansouri Maryam, Hojat Bita, Kaveh Samani Marzieh, Veisi Razieh, Honarvar Bakeshloo Parisa, Nosratipour Reza, Afkhami Hamed, Saeb Sepideh
Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Front Oncol. 2025 Feb 24;15:1499094. doi: 10.3389/fonc.2025.1499094. eCollection 2025.
Colorectal cancer (CRC) is a common and lethal malignancy that affects millions of people worldwide. Iron is an essential micronutrient that plays a vital role in various biological processes, but also has pro-oxidant and pro-inflammatory effects that may contribute to carcinogenesis. The relationship between iron and CRC is complex and influenced by multiple factors, such as dietary intake, absorption, storage, metabolism, and excretion of iron, as well as genetic and environmental factors that modulate iron homeostasis. This review article aims to provide an overview of the current evidences on the role of iron in CRC, discussing the potential mechanisms by which iron may affect CRC development and progression, as well as the implications for prevention and treatment. This review tries to focus on the following aspects: an introduction to iron and its role in CRC, role of heme and non-heme iron in CRC, dietary patterns, nutrition, and CRC, iron overload in CRC, iron deficiency and its role in CRC especially in surgery outcome and iron therapy and blood transfusion in CRC.
结直肠癌（CRC）是一种常见的致命恶性肿瘤，全球数百万人受其影响。铁是一种必需的微量营养素，在各种生物过程中起着至关重要的作用，但也具有促氧化和促炎作用，可能有助于致癌。铁与结直肠癌之间的关系很复杂，受多种因素影响，如铁的饮食摄入、吸收、储存、代谢和排泄，以及调节铁稳态的遗传和环境因素。这篇综述文章旨在概述目前关于铁在结直肠癌中作用的证据，讨论铁可能影响结直肠癌发生和发展的潜在机制，以及对预防和治疗的意义。本综述试图聚焦于以下方面：铁及其在结直肠癌中的作用介绍、血红素铁和非血红素铁在结直肠癌中的作用、饮食模式、营养与结直肠癌、结直肠癌中的铁过载、铁缺乏及其在结直肠癌中的作用，特别是在手术结果方面，以及结直肠癌中的铁疗法和输血。
