Alasnag Mirvat, AlHabeeb Waleed, Khaliel Feras
Cardiac Center, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.
Department of Cardiac Sciences, King Saud University, Riyadh, Saudi Arabia.
J Saudi Heart Assoc. 2025 Feb 5;37(1):6. doi: 10.37616/2212-5043.1418. eCollection 2025.
The totality of evidence suggests that there remains a significant disparity in the use of left ventricular assist devices (LVADs) and heart transplantation (HT) in women. This disparity persists even after accounting for differences in baseline characteristics, comorbidities, and cardiovascular risk factors between men and women undergoing LVAD implantation as a bridge to HT. Generally, women are less likely to undergo HT, leading to a higher mortality rate in women on the HT waiting list. The differences in risk profiles and device-related complications may account for the sexrelated disparities in the assignment of device therapies. These findings warrant an urgent need to conduct prospective studies to better define this conundrum and establish guidelines to narrow the current gaps in care.
所有证据表明，女性在使用左心室辅助装置（LVAD）和心脏移植（HT）方面仍存在显著差异。即使在考虑了接受LVAD植入作为HT过渡的男性和女性之间的基线特征、合并症和心血管危险因素差异之后，这种差异仍然存在。一般来说，女性接受HT的可能性较小，这导致HT等待名单上的女性死亡率更高。风险特征和与装置相关的并发症差异可能是装置治疗分配中性别差异的原因。这些发现迫切需要进行前瞻性研究，以更好地界定这一难题，并制定指导方针以缩小目前的护理差距。
