Calicchio Francesca, Epstein Elizabeth, Boussoussou Melinda, Vattay Borbála, van Rosendael Alexander, Newlander Shawn, Kolossváry Márton, Szilveszter Bálint, Maurovich-Horvat Pál, Marques Hugo, McVeigh Elliot, Wesbey George
Department of Cardiology and Radiology, Scripps Clinic, 9888 Genesee Ave, La Jolla, CA 92037, USA.
Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary.
Eur Heart J Imaging Methods Pract. 2025 Jan 29;3(1):qyaf014. doi: 10.1093/ehjimp/qyaf014. eCollection 2025 Jan.
This review article explores the challenges and controversies involved in accurately identifying and reliably quantifying coronary plaque over time through coronary computed tomography angiography (CCTA), particularly focusing on lipid-rich, low-attenuation plaques. It highlights significant variability in lipid-rich plaque measurements across studies, questioning their reliability for tracking biological plaque transformation in clinical practice. To address this issue, the review article proposes suggestions for serial CCTA plaque measurements, aiming for realistic goals for reproducible and meaningful serial plaque CCTA imaging. It also emphasizes the necessity of standardized, validated methods for quantitative plaque analysis and underscores the potential of phantom-based calibration to improve the reliability and consistency of serial plaque measurements in clinical practice.
这篇综述文章探讨了通过冠状动脉计算机断层扫描血管造影（CCTA）随时间准确识别和可靠量化冠状动脉斑块所涉及的挑战和争议，尤其关注富含脂质的低衰减斑块。它强调了不同研究中富含脂质斑块测量的显著变异性，质疑其在临床实践中追踪生物斑块转变的可靠性。为解决这一问题，该综述文章提出了连续CCTA斑块测量的建议，旨在实现可重复且有意义的连续斑块CCTA成像的现实目标。它还强调了标准化、经过验证的定量斑块分析方法的必要性，并强调了基于体模校准在提高临床实践中连续斑块测量的可靠性和一致性方面的潜力。
