Zhou Jiaji, Du Wenyi, Huang Hanzhou, Chen Yongqi, Li Huixing, Chen Leyan, Liu Feng, Zheng Mingfeng
Department of Thoracic Surgery, Wuxi People's Hospital, Nanjing Medical University, Wuxi Medical Center, Wuxi, China.
Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi, China.
Front Med (Lausanne). 2025 Feb 24;12:1503142. doi: 10.3389/fmed.2025.1503142. eCollection 2025.
Chronic respiratory diseases (CRPD) are a global health threat characterized by oxidative stress, systemic inflammation, hypoxemia, and respiratory distress. Inflammatory indicators such as hemoglobin-to-red blood cell distribution width ratio (HRR) have been explored in relation to diseases of the respiratory system, but the correlation between HRR and pulmonary function has not been established. As part of this study, a representative sample of the National Health and Nutrition Examination Survey (NHANES) respondents aged 40 or over was used to examine the correlation between HRR and pulmonary function indices.
Data from the 2007-2012 NHANES were used for this study. HRR and four pulmonary function parameters were compared using regression and subgroup analyses. The Restricted Cubic Spline (RCS) model was employed to find out if there are any non-linear relationships between these associations. Multiple sensitivity analyses were used to verify the correlation between the two.
After adjusting for confounding variables, the data showed that for each unit increase in HRR among the population as a whole, for each unit increase in HRR, FVC increased by 0.11, FEV1 increased by 0.22, peak expiratory flow (PEF) increased by 0.24 and forced expiratory flow at 25-75% (FEF25-75%) was elevated by 0.49. In addition, we determined linear and positive correlations between FVC, FEV1, PEF or PEF 25-75% and HRR by constructing the RCS model curves. The positive correlation between HRR and pulmonary function parameters was affirmed through sensitivity analysis. Furthermore, except for the PEF 25-75%, FVC, FEV1, PEF all showed a significant upward trend with the increase of HRR in non-Hispanic white female population.
According to our study, HRR was positively correlated with FVC, FEV1, PEF, and PEF25-75% in a middle-aged and older adult US population. It would be useful to study the specific impact of HRR on pulmonary function and to investigate the potential pathophysiological mechanisms that might link them.
慢性呼吸道疾病（CRPD）是一种全球性健康威胁，其特征为氧化应激、全身炎症、低氧血症和呼吸窘迫。诸如血红蛋白与红细胞分布宽度比值（HRR）等炎症指标已在与呼吸系统疾病的关联中进行了探索，但HRR与肺功能之间的相关性尚未确立。作为本研究的一部分，使用了美国国家健康与营养检查调查（NHANES）中40岁及以上受访者的代表性样本，来研究HRR与肺功能指标之间的相关性。
本研究使用了2007 - 2012年NHANES的数据。使用回归分析和亚组分析比较了HRR和四个肺功能参数。采用限制立方样条（RCS）模型来探究这些关联之间是否存在任何非线性关系。使用多种敏感性分析来验证两者之间的相关性。
在调整混杂变量后，数据显示，在总体人群中，HRR每增加一个单位，用力肺活量（FVC）增加0.11，第一秒用力呼气容积（FEV1）增加0.22，呼气峰值流速（PEF）增加0.24，25% - 75%用力呼气流量（FEF25 - 75%）升高0.49。此外，通过构建RCS模型曲线，我们确定了FVC、FEV1、PEF或FEF25 - 75%与HRR之间呈线性正相关。通过敏感性分析确认了HRR与肺功能参数之间的正相关。此外，除了FEF25 - 75%外，在非西班牙裔白人女性人群中，FVC、FEV1、PEF均随着HRR的增加呈现显著上升趋势。
根据我们的研究，在美国中老年人群中，HRR与FVC、FEV1、PEF和FEF25 - 75%呈正相关。研究HRR对肺功能的具体影响以及探究可能将它们联系起来的潜在病理生理机制将是有益的。
