McCray Lauren R, Scharner Megan K, Nguyen Shaun A, Rizk Habib G, Meyer Ted A, Labadie Robert F, Uhde Thomas W, Dixon Peter R
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Baylor College of Medicine, Houston, Texas, USA.
Laryngoscope. 2025 Mar 11. doi: 10.1002/lary.32118.
To assess relations between tinnitus and suicidality, measured by suicidal ideation and suicide attempts.
CINAHL, Cochrane Library, PubMed, PsycINFO, and SCOPUS databases were searched from inception through June 14, 2024.
Observational studies related to suicidality in tinnitus patients at least 18 years old were included. Case reports and studies on objective or pulsatile tinnitus were excluded. Two authors extracted data, and disagreements were resolved with a third party if needed. The risk of bias was assessed according to the Risk Of Bias In Non-randomized Studies of Exposure for cohort studies and the Joanna Briggs Institute critical appraisal checklist for cross-sectional studies. Random effects meta-analyses (single means, proportions, and relative risks (RR)) were used for primary analysis.
Nine studies (n = 912,013) pertaining to suicidality and tinnitus in an adult population were included. The tinnitus group experienced a significantly higher prevalence of suicidal ideation (19.5% [95% CI: 12.9%-27.1%] versus 9.9% [95% CI: 7.1%-13.2%]) and suicide attempts (1.9% [95% CI: 0.1%-5.7%] versus 0.9% [95% CI: 0.0%-3.9%]) than the control population (p < 0.0001). The tinnitus group had a significantly (p < 0.001) higher risk of suicidal ideation (RR = 2.1, 95% CI: 1.6-2.8) and suicide attempts (RR = 1.8, 95% CI: 1.3-2.4) than the control group.
Nearly one in five people with tinnitus will experience suicidal ideation, and nearly 2% will attempt suicide. Thus, otolaryngologists should be mindful of the increased risk of suicidality in patients with tinnitus.
通过自杀意念和自杀未遂来评估耳鸣与自杀倾向之间的关系。
对CINAHL、考克兰图书馆、PubMed、PsycINFO和SCOPUS数据库自创建起至2024年6月14日进行检索。
纳入至少18岁耳鸣患者中与自杀倾向相关的观察性研究。排除病例报告以及关于客观性或搏动性耳鸣的研究。两名作者提取数据，如有分歧则与第三方协商解决。根据队列研究的非随机暴露研究中的偏倚风险以及横断面研究的乔安娜·布里格斯研究所批判性评价清单评估偏倚风险。采用随机效应荟萃分析（单均值、比例和相对风险（RR））进行初步分析。
纳入了9项关于成年人群中自杀倾向与耳鸣的研究（n = 912,013）。耳鸣组的自杀意念患病率（19.5% [95%置信区间：12.9% - 27.1%] 对比9.9% [95%置信区间：7.1% - 13.2%]）和自杀未遂率（1.9% [95%置信区间：0.1% - 5.7%] 对比0.9% [95%置信区间：0.0% - 3.9%]）均显著高于对照组（p < 0.0001）。耳鸣组的自杀意念风险（RR = 2.1，95%置信区间：1.6 - 2.8）和自杀未遂风险（RR = 1.8，95%置信区间：1.3 - 2.4）显著高于对照组（p < 0.001）。
近五分之一的耳鸣患者会出现自杀意念，近2%的患者会尝试自杀。因此，耳鼻喉科医生应注意耳鸣患者自杀倾向增加的风险。
