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Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action.

作者信息

Neopane Deepa, Kushwaha Poonam

机构信息

Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, 226026, India.

出版信息

Pharmacol Rep. 2025 Jun;77(3):610-623. doi: 10.1007/s43440-025-00709-6. Epub 2025 Mar 11.


DOI:10.1007/s43440-025-00709-6
PMID:40067636
Abstract

Asthma, a chronic inflammatory disorder of the airways, remains a significant global health concern. Current treatments focus on symptom management and inflammation control, but the search for more effective and safer therapies continues. Carvacrol, a naturally occurring monoterpenoid phenol found in essential oils of various plants, has emerged as a promising bioactive compound with potent anti-inflammatory, antioxidant, and bronchodilatory properties. This review explores the potential of carvacrol as a novel therapeutic agent for asthma management. We discuss its mechanisms of action, including modulation of inflammatory pathways, inhibition of oxidative stress, and relaxation of bronchial muscles. Additionally, preclinical and clinical studies evaluating the efficacy and safety of carvacrol in asthma treatment are analyzed. The integration of carvacrol into existing treatment regimens could offer a multifaceted approach to asthma management, enhancing therapeutic outcomes and improving patients' quality of life.

摘要

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本文引用的文献

[1]
Protective effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction - A comprehensive review.

Food Sci Nutr. 2024-2-5

[2]
Carvacrol-A Natural Phenolic Compound with Antimicrobial Properties.

Antibiotics (Basel). 2023-4-27

[3]
Antibacterial and anti-biofilm properties of carvacrol alone and in combination with cefixime against Escherichia coli.

BMC Microbiol. 2023-3-3

[4]
Antimicrobial and Antivirulence Activities of Carvacrol against Pathogenic .

Microorganisms. 2022-10-31

[5]
Therapeutic application of carvacrol: A comprehensive review.

Food Sci Nutr. 2022-8-3

[6]
Airway smooth muscle function in asthma.

Front Physiol. 2022-10-5

[7]
Current Understanding of Asthma Pathogenesis and Biomarkers.

Cells. 2022-9-5

[8]
Anti-Inflammatory and Antioxidant Effects of Carvacrol on -Methyl-'-Nitro--Nitrosoguanidine (MNNG) Induced Gastric Carcinogenesis in Wistar Rats.

Nutrients. 2022-7-12

[9]
Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways.

Curr Mol Pharmacol. 2023-3-27

[10]
Neuroprotective effects of carvacrol against Alzheimer's disease and other neurodegenerative diseases: A review.

Avicenna J Phytomed. 2022

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