Khazdair Mohammad Reza, Moshtagh Mozhgan, Anaeigoudari Akbar, Jafari Shima, Kazemi Toba
Cardiovascular Diseases Research Center Birjand University of Medical Sciences Birjand Iran.
Social Determinants of Health Research Center Birjand University of Medical Sciences Birjand Iran.
Food Sci Nutr. 2024 Feb 5;12(5):3137-3149. doi: 10.1002/fsn3.4014. eCollection 2024 May.
Cardiovascular diseases (CVDs) are a class of illnesses that affect the heart or blood vessels, leading to the most common causes of death worldwide. In 2017, CVD caused approximately 17.8 million deaths that were increased approximately to 20.5 million deaths in 2021, globally. Also, nearly 80% of worldwide CVD deaths occur in some countries. Some herbs and their constituents due to their several pharmacological activities have been used for medicinal purposes. Carvacrol is a phenolic mono-terpenoid found in the oils of aromatic herbs with several biological properties. The possible therapeutic effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction were summarized in the current study. The data from this review article were obtained by searching the terms including; "Carvacrol", "Hypertension", Hypotensive, "Cardiac dysfunction", "Ischemia", "Lipid profile", and Oxidative stress in several web databases such as Web of Sciences, PubMed Central, and Google Scholar, until November 2023. The results of the reviewed studies revealed that carvacrol inhibits acetylcholinesterase (AchE) activity and alters lipid profiles, reducing heart rate as well as systolic and diastolic blood pressure (BP). Carvacrol also decreased the proinflammatory cytokine (IL-1β), while increasing secretion of anti-inflammatory cytokine (IL-10). Moreover, carvacrol improved oxidative stress and mitigated the number of apoptotic cells. The pharmacological effects of carvacrol on CVD might be through its antioxidative, anti-inflammatory, and antiapoptotic effects. The mentioned therapeutic effects of carvacrol on lipid profile, hypertension, and cardiac dysfunction indicate the possible remedy effect of carvacrol for the treatment of CVD.
心血管疾病（CVDs）是一类影响心脏或血管的疾病，是全球最常见的死亡原因。2017年，心血管疾病导致全球约1780万人死亡，到2021年这一数字增至约2050万人。此外，全球近80%的心血管疾病死亡发生在一些国家。一些草药及其成分因其多种药理活性而被用于药用。香芹酚是一种酚类单萜，存在于芳香草药的油中，具有多种生物学特性。本研究总结了香芹酚对血脂、氧化应激、高血压和心脏功能障碍的可能治疗作用。这篇综述文章的数据是通过在科学网、公共医学中心和谷歌学术等多个网络数据库中搜索 “香芹酚”、“高血压”、“降压”、“心脏功能障碍”、“缺血”、“血脂” 和 “氧化应激” 等关键词获得的，截至2023年11月。综述研究结果表明，香芹酚可抑制乙酰胆碱酯酶（AchE）活性，改变血脂，降低心率以及收缩压和舒张压（BP）。香芹酚还可降低促炎细胞因子（IL-1β），同时增加抗炎细胞因子（IL-10）的分泌。此外，香芹酚可改善氧化应激并减少凋亡细胞数量。香芹酚对心血管疾病的药理作用可能是通过其抗氧化、抗炎和抗凋亡作用实现的。香芹酚对血脂、高血压和心脏功能障碍的上述治疗作用表明，香芹酚可能对心血管疾病具有治疗作用。
