Drexel H, Lang A H, Spiegel R W, Abbrederis K
Dtsch Med Wochenschr. 1985 Jul 5;110(27):1063-7. doi: 10.1055/s-2008-1068959.
The continuous subcutaneous infusion of opiate, a new approach to the alleviation of severe chronic pain, has been carried out using a pump system normally employed for the infusion of insulin. Relapses of pain can be controlled with bolus doses. This mode of application was compared with conventional therapy in 11 patients. All patients were free of pain during the continuous infusion, but none showed a satisfactory response during conventional treatment. The improved response under continuous opiate infusion was attained with much lower doses and thus with fewer side effects. The procedure is therefore highly effective and well tolerated.
皮下持续输注阿片类药物是缓解严重慢性疼痛的一种新方法，该方法使用的是通常用于输注胰岛素的泵系统。疼痛复发可用大剂量推注控制。在11例患者中，将这种给药方式与传统疗法进行了比较。在持续输注期间，所有患者均无疼痛，但在传统治疗期间，无一例显示出满意的反应。持续输注阿片类药物时，以更低的剂量即可获得更好的反应，因此副作用更少。该方法因此高效且耐受性良好。
