Kuş Mine Müjde, Yaray Ozan Can, Öztürk Perihan, Mülayim Mehmet Kamil
Department of Dermatology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Medicine (Baltimore). 2025 Mar 7;104(10):e41747. doi: 10.1097/MD.0000000000041747.
Recently, immature granulocyte count (IGC) in an automated blood cell counter was introduced as a new inflammatory marker. We aimed to evaluate the relationship between the IGC and percentage of immature granulocyte (IG%) and disease activity in patients with pemphigus. Pemphigus disease area index (PDAI), IGC, IG%, C-reactive protein, neutrophil/lymphocyte ratios, platelet-to-lymphocyte ratio (PLR), anti-desmoglein 1, and anti-desmoglein 3 levels in patients with pemphigus were recorded retrospectively, and the statistical relationship between them was evaluated. Repetitive intra-patient blood samples (74 blood samples) and PDAIs (74 PDAI scores) of 24 patients (12 men, 12 women; mean age 56.30 ± 16.47 years) were included in the study. There was no correlation between PDAI and anti-desmoglein 1, anti-desmoglein 3 levels, and neutrophil/lymphocyte ratio (r = 0.040, P = .737; r = 0.007, P = .952; r = 0.224, P = .055, respectively). A statistically low positive correlation was detected between PDAI and C-reactive protein (r = 0.243, P = .037). There was a moderate positive correlation between PDAI and IGC, IG%, and PLR (r = 0.435, P < .001; r = 0.412, P < .001; r = 0.376, P = .001, respectively). The effects of independent variables in predicting PDAI were evaluated using multiple linear regression analysis. Accordingly, the cutoff value of the IGC and PLR positively significantly affect the PDAI score (P < .05). A 1-unit increase in PLR indicates a 0.009 times increase in PDAI, and a 1-unit increase exceeding the IG cutoff value indicates a 2.836 times increase in PDAI. The IGC and IG% can be used to evaluate pemphigus disease activity.
最近，自动血细胞计数器中的未成熟粒细胞计数（IGC）作为一种新的炎症标志物被引入。我们旨在评估天疱疮患者中IGC与未成熟粒细胞百分比（IG%）以及疾病活动度之间的关系。回顾性记录天疱疮患者的天疱疮疾病面积指数（PDAI）、IGC、IG%、C反应蛋白、中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值（PLR）、抗桥粒芯糖蛋白1和抗桥粒芯糖蛋白3水平，并评估它们之间的统计关系。本研究纳入了24例患者（12例男性，12例女性；平均年龄56.30±16.47岁）的74份患者重复血样和74个PDAI评分。PDAI与抗桥粒芯糖蛋白1、抗桥粒芯糖蛋白3水平以及中性粒细胞/淋巴细胞比值之间无相关性（r = 0.040，P = 0.737；r = 0.007，P = 0.952；r = 0.224，P = 0.055）。PDAI与C反应蛋白之间检测到统计学意义上的低度正相关（r = 0.243，P = 0.037）。PDAI与IGC、IG%和PLR之间存在中度正相关（r分别为0.435，P < 0.001；r = 0.412，P < 0.001；r = 0.376，P = 0.001）。使用多元线性回归分析评估自变量在预测PDAI中的作用。据此，IGC和PLR的截断值对PDAI评分有显著正向影响（P < 0.05）。PLR每增加1个单位表明PDAI增加0.009倍，超过IG截断值每增加1个单位表明PDAI增加2.836倍。IGC和IG%可用于评估天疱疮疾病活动度。
