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儿童甲状腺功能减退症伴股骨骨骺滑脱延迟:一例报告。

Delayed slipped capital femoral epiphysis with hypothyroidism in children: A case report.

作者信息

Zhao Qinggang, Hu Xingxi, Lei Yihao, Guo Fengyong, Hou Kaiyu, Deng Yongcheng, Chen Zhong, Jiang Junliang, Chen Ge

机构信息

Department of Orthopedics and Traumatology, The Affiliated Hospital of Yunnan University, Kunming, Yunnan Province, China.

出版信息

Medicine (Baltimore). 2025 Mar 7;104(10):e41789. doi: 10.1097/MD.0000000000041789.

Abstract

RATIONALE

Slipped capital femoral epiphysis (SCFE) is a common adolescent hip disorder, but its association with hypothyroidism remains rare and poorly understood. This case highlights the importance of considering endocrine disorders, such as hypothyroidism, as potential risk factors in atypical SCFE presentations, particularly when trauma or other common etiologies are absent.

PATIENT CONCERNS

A 14-year-old boy presented with progressive, nontraumatic left hip pain that worsened over 6 weeks, eventually leading to complete immobility. Initially managed unsuccessfully with traditional Chinese medicine, the patient sought care at a trauma center before referral to our hospital.

DIAGNOSES

Imaging confirmed a delayed, moderate SCFE of the left hip, characterized by posteromedial displacement of the femoral epiphysis. Laboratory tests revealed significant hypothyroidism, with elevated thyroid-stimulating hormone (>100 μIU/mL) and reduced thyroid hormone levels (FT4, FT3, TT3, TT4).

INTERVENTIONS

The patient underwent open reduction and internal fixation using 4 Kirschner wires via an anterolateral approach, followed by immobilization in a hip spica cast for 2 months. Postoperatively, hypothyroidism was managed with levothyroxine (50 μg/day) under endocrinological supervision.

OUTCOMES

After 2 years of follow-up, the patient achieved full functional recovery with no evidence of complications, such as avascular necrosis or residual deformity. Bone union was complete by 8 weeks, and normal activity resumed within 5.5 months.

LESSONS

This case underscores the need to screen for thyroid dysfunction in pediatric SCFE patients lacking typical risk factors, such as trauma or obesity. Early recognition and interdisciplinary management of both orthopedic and endocrine aspects can optimize outcomes and prevent long-term complications, emphasizing the value of a comprehensive diagnostic approach.

摘要

理论依据

股骨头骨骺滑脱(SCFE)是一种常见的青少年髋关节疾病,但其与甲状腺功能减退的关联仍然罕见且了解不足。本病例强调了将内分泌疾病(如甲状腺功能减退)视为非典型SCFE表现潜在危险因素的重要性,特别是在没有创伤或其他常见病因的情况下。

患者情况

一名14岁男孩出现进行性、非创伤性左髋疼痛,在6周内加重,最终导致完全无法活动。最初接受中医治疗但未成功,患者在转诊至我院之前在一家创伤中心寻求治疗。

诊断

影像学检查证实为左髋延迟性、中度SCFE,特征为股骨头骨骺向后内侧移位。实验室检查显示严重甲状腺功能减退,促甲状腺激素升高(>100 μIU/mL),甲状腺激素水平降低(FT4、FT3、TT3、TT4)。

干预措施

患者通过前外侧入路使用4根克氏针进行切开复位内固定,随后用髋人字石膏固定2个月。术后,在内分泌科监督下用左甲状腺素(50 μg/天)治疗甲状腺功能减退。

结果

经过2年随访,患者实现了完全功能恢复,没有出现诸如缺血性坏死或残留畸形等并发症的迹象。8周时骨愈合完成,5.5个月内恢复正常活动。

经验教训

本病例强调了对缺乏典型危险因素(如创伤或肥胖)的小儿SCFE患者进行甲状腺功能障碍筛查的必要性。对骨科和内分泌方面进行早期识别和多学科管理可以优化治疗效果并预防长期并发症,强调了综合诊断方法的价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bff/11902969/411f0ab2bb39/medi-104-e41789-g001.jpg

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