Ghavami Zahra, Amiri Bezat, Haddad Mahboubeh, Khoroushi Farzaneh, Abedi Farshad, Elyasi Sepideh, Sheybani Fereshte
Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
J Med Case Rep. 2025 Mar 11;19(1):108. doi: 10.1186/s13256-025-05145-x.
Brucellosis is one of the most prevalent zoonotic diseases worldwide, posing a significant public health concern across both developed and developing nations. While musculoskeletal system involvement is the most common form of focal brucellosis, the genitourinary system represents the second most affected site. However, Brucella-related kidney involvement remains a rare manifestation of genitourinary brucellosis.
We herein present the case of a 55-year-old Iranian male patient, initially admitted with symptoms indicative of osteoarticular brucellosis, who subsequently developed pyelonephritis confirmed by positive urine culture for Brucella. He was treated with gentamicin for 10 days and rifampin and doxycycline for a period of 6 weeks. The patient fully recovered.
Our case highlights the importance of considering brucellosis as a potential cause of pyelonephritis, especially where brucellosis is endemic and when musculoskeletal involvement is present. Additionally, a comprehensive review of the literature on kidney involvement in brucellosis was conducted to provide further insights into this condition. Clinical Trial number Not applicable.
布鲁氏菌病是全球最普遍的人畜共患病之一,在发达国家和发展中国家均引起了重大的公共卫生关注。虽然肌肉骨骼系统受累是局灶性布鲁氏菌病最常见的形式,但泌尿生殖系统是第二大受影响部位。然而,布鲁氏菌相关的肾脏受累仍然是泌尿生殖系统布鲁氏菌病的罕见表现。
我们在此介绍一名55岁的伊朗男性患者,最初因提示骨关节炎性布鲁氏菌病的症状入院,随后经尿液培养布鲁氏菌阳性确诊为肾盂肾炎。他接受了10天的庆大霉素治疗以及为期6周的利福平和强力霉素治疗。患者完全康复。
我们的病例强调了将布鲁氏菌病视为肾盂肾炎潜在病因的重要性,特别是在布鲁氏菌病流行且存在肌肉骨骼受累的情况下。此外,还对有关布鲁氏菌病肾脏受累的文献进行了全面综述,以提供对这种情况的进一步见解。临床试验编号不适用。