Su Peng, Du Guotu, Yang Ying, Zheng Hong, Zhang Neng
Department of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Front Med (Lausanne). 2025 Jul 10;12:1613953. doi: 10.3389/fmed.2025.1613953. eCollection 2025.
Polycystic kidney disease (PKD) is a common genetic disorder characterized by the progressive development of multiple renal cysts. While cyst infections in PKD are typically caused by common gut flora, infections due to atypical zoonotic pathogens like are exceedingly rare. We present a unique case of a 40-year-old male patient with PKD who developed a renal cyst infection caused by following exposure to livestock. Despite initial negative urine cultures, blood cultures confirmed the diagnosis of infection. The patient was successfully treated with a combination of doxycycline and rifampin. This case underscores the importance of considering zoonotic pathogens in patients with PKD and a history of livestock contact. It also highlights the critical role of early diagnosis and targeted antibiotic therapy in managing such rare infections. Additionally, this study provides a comprehensive review of brucellosis, covering its epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment strategies.
多囊肾病(PKD)是一种常见的遗传性疾病,其特征是多个肾囊肿逐渐发展。虽然PKD中的囊肿感染通常由常见的肠道菌群引起,但由非典型人畜共患病原体如[此处原文缺失病原体名称]引起的感染极为罕见。我们报告了一例独特的病例,一名40岁患有PKD的男性患者在接触牲畜后发生了由[此处原文缺失病原体名称]引起的肾囊肿感染。尽管最初尿液培养结果为阴性,但血培养确诊了[此处原文缺失病原体名称]感染。该患者通过强力霉素和利福平联合治疗成功治愈。该病例强调了在患有PKD且有牲畜接触史的患者中考虑人畜共患病原体的重要性。它还突出了早期诊断和针对性抗生素治疗在管理此类罕见感染中的关键作用。此外,本研究对布鲁氏菌病进行了全面综述,涵盖其流行病学、发病机制、临床表现、诊断和治疗策略。