Solesvik O V, Rofstad E K, Brustad T
Eur J Cancer Clin Oncol. 1985 Apr;21(4):499-505. doi: 10.1016/0277-5379(85)90044-6.
The vascular system of three commonly used murine experimental tumours, the C3H mammary carcinoma, the B16 melanoma and the Lewis lung carcinoma, in syngeneic (C3D2F1/Bom or C57BL/6J/Bom) and athymic (BALB/c/nu/nu/Bom) mice was studied. The main vascular characteristics of each tumour, i.e. the mean vessel diameter, the total vessel volume and the distribution of the total vessel volume among vessels with different diameters, did not change upon transplantation from conventional to athymic mice. However, the length of vessels with diameters in the range 5-15 micron was for all tumours shorter in athymic than in conventional mice. The vascular volume of the B16 melanoma per unit histologically intact tumour volume in athymic mice (0.040 +/- 0.004) was considerably larger than that of five human melanoma xenografts previously studied (0.009 +/- 0.001 to 0.022 +/- 0.002). This difference was mainly due to occurrence of vessels with diameters in the range 55-145 micron in the B16 melanoma; vessels which were generally not observed in the human melanoma xenografts.
研究了同基因（C3D2F1/Bom或C57BL/6J/Bom）和无胸腺（BALB/c/nu/nu/Bom）小鼠体内三种常用的鼠类实验肿瘤（C3H乳腺癌、B16黑色素瘤和Lewis肺癌）的血管系统。每种肿瘤的主要血管特征，即平均血管直径、总血管体积以及总血管体积在不同直径血管中的分布，在从传统小鼠移植到无胸腺小鼠后并未改变。然而，对于所有肿瘤，无胸腺小鼠体内直径在5 - 15微米范围内的血管长度比传统小鼠的短。无胸腺小鼠中B16黑色素瘤每单位组织学完整肿瘤体积的血管体积（0.040±0.004）显著大于先前研究的五个人类黑色素瘤异种移植瘤（0.009±0.001至0.022±0.002）。这种差异主要是由于B16黑色素瘤中存在直径在55 - 145微米范围内的血管；而在人类黑色素瘤异种移植瘤中通常未观察到这类血管。
