Rofstad E K
Cell Tissue Kinet. 1984 Jan;17(1):91-101. doi: 10.1111/j.1365-2184.1984.tb00571.x.
The growth and the vascular structure of five human melanomas grown in athymic nude mice were studied. Four growth parameters (tumour volume doubling time, fraction of cells in S-phase, growth fraction, cell-loss factor) were analysed against each of four vascular parameters (length of vessels with diameters in the range 5-15 micron, total vessel length, total vessel surface, total vessel volume--all per unit of histologically intact tumour volume). Statistically significant linear correlations between the parameters were found for any of the combinations. However, there was a consistent trend in the data: the tumour volume doubling time and the cell-loss factor tended to decrease while the fraction of cells in S-phase and the growth fraction tended to increase with increasing vascular density, whichever vascular parameter was considered. This finding indicates that the vascular density is among the factors which are decisive for the growth rate of tumours. However, the present work does not exclude the possibility that intrinsic properties of the tumour cells may also be important.
对五只在无胸腺裸鼠体内生长的人类黑色素瘤的生长及血管结构进行了研究。针对四个血管参数（直径在5 - 15微米范围内的血管长度、血管总长度、血管总表面积、血管总体积——均为每单位组织学完整肿瘤体积）中的每一个，分析了四个生长参数（肿瘤体积倍增时间、S期细胞分数、生长分数、细胞丢失因子）。在任何参数组合之间均发现了具有统计学意义的线性相关性。然而，数据中存在一个一致的趋势：无论考虑哪个血管参数，随着血管密度增加，肿瘤体积倍增时间和细胞丢失因子趋于降低，而S期细胞分数和生长分数趋于增加。这一发现表明血管密度是决定肿瘤生长速率的因素之一。然而，目前的研究并不排除肿瘤细胞的内在特性也可能很重要的可能性。
