Mangalik A, Robinson W A, Drebing C, Hartmann D, Joshi J H
Exp Hematol. 1979;7 Suppl 5:76-94.
A program of nonfrozen autologous bone marrow rescue was used to treat patients with refractory nonhematological neoplasms. In vitro storage of bone marrow cells and CFU-C suggests that storage at 4 degrees or 10 degrees for periods up to five days can be undertaken with only minor loss of CFU-C. However, since the loss occurred in a gradual fashion, shorter duration of storage would probably be better. Hematological recovery after high dose chemotherapy occurred faster in patients given more CFU-C and those with shortest duration of storage prior to reinfusion.
采用非冷冻自体骨髓挽救方案治疗难治性非血液系统肿瘤患者。骨髓细胞和集落形成单位 - 细胞(CFU - C)的体外储存表明,在4℃或10℃下储存长达五天,CFU - C仅有轻微损失。然而,由于损失是逐渐发生的,较短的储存时间可能更好。接受更多CFU - C且再输注前储存时间最短的患者,高剂量化疗后的血液学恢复更快。