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骨髓的液体储存

Liquid storage of bone marrow.

作者信息

Mangalik A, Robinson W A, Drebing C, Hartmann D, Joshi J H

出版信息

Exp Hematol. 1979;7 Suppl 5:76-94.

PMID:400704
Abstract

A program of nonfrozen autologous bone marrow rescue was used to treat patients with refractory nonhematological neoplasms. In vitro storage of bone marrow cells and CFU-C suggests that storage at 4 degrees or 10 degrees for periods up to five days can be undertaken with only minor loss of CFU-C. However, since the loss occurred in a gradual fashion, shorter duration of storage would probably be better. Hematological recovery after high dose chemotherapy occurred faster in patients given more CFU-C and those with shortest duration of storage prior to reinfusion.

摘要

采用非冷冻自体骨髓挽救方案治疗难治性非血液系统肿瘤患者。骨髓细胞和集落形成单位 - 细胞(CFU - C)的体外储存表明,在4℃或10℃下储存长达五天,CFU - C仅有轻微损失。然而,由于损失是逐渐发生的,较短的储存时间可能更好。接受更多CFU - C且再输注前储存时间最短的患者,高剂量化疗后的血液学恢复更快。

相似文献

1
Liquid storage of bone marrow.骨髓的液体储存
Exp Hematol. 1979;7 Suppl 5:76-94.
2
CFU-GEMM correlate with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high-dose melphalan chemotherapy.在接受大剂量美法仑化疗后进行自体骨髓移植的患者中,粒系-红系-单核系-巨核系集落形成单位与中性粒细胞和血小板的恢复相关。
Bone Marrow Transplant. 1987 Aug;2(2):165-73.
3
Proliferative response of human marrow myeloid progenitor cells to in vivo treatment with granulocyte colony-stimulating factor alone and in combination with interleukin-3 after autologous bone marrow transplantation.自体骨髓移植后,人骨髓髓系祖细胞对单独使用粒细胞集落刺激因子以及联合白细胞介素-3进行体内治疗的增殖反应。
Exp Hematol. 1995 Dec;23(14):1520-6.
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Recovery of CFU-GM from cryopreserved marrow and in vivo evaluation after autologous bone marrow transplantation are predictive of engraftment.从冷冻保存的骨髓中恢复CFU-GM以及自体骨髓移植后的体内评估可预测植入情况。
Exp Hematol. 1986 Jun;14(5):358-65.
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[Cryopreservation of bone marrow for the autologous transplantation in children].[儿童自体移植骨髓的冷冻保存]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(1):62-77.
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Dilution techniques for optimum recovery of cryopreserved bone marrow cells.
Exp Hematol. 1979;7 Suppl 5:1-6.
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Viability of haemopoietic progenitors from whole blood, bone marrow and leukapheresis product: effects of storage media, temperature and time.全血、骨髓和白细胞分离产物中造血祖细胞的活力:储存介质、温度和时间的影响。
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Fresh PBSC harvests, but not BM, show temperature-related loss of CD34 viability during storage and transport.新鲜采集的外周血造血干细胞(PBSC),而非骨髓(BM),在储存和运输过程中显示出与温度相关的CD34活力丧失。
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Prediction of the optimal timing of bone marrow reinfusion after high dose chemotherapy.
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Effects of marrow storage at 4 degrees C on the subsequent generation of long-term marrow cultures.
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引用本文的文献

1
Storage of noncryopreserved periphered blood stem cells for transplantation.用于移植的非冷冻保存外周血干细胞的储存。
Ann Hematol. 1996 May;72(5):303-6. doi: 10.1007/s002770050176.
2
High-dose nitrogen mustard (HN2) with autologous nonfrozen bone marrow transplantation in advanced malignant melanoma. A phase I trial.高剂量氮芥(HN2)联合自体非冷冻骨髓移植治疗晚期恶性黑色素瘤。一项I期试验。
Blut. 1981 Apr;42(4):209-20. doi: 10.1007/BF00996750.
3
Hematopoietic reconstitution after high-dose chemotherapy and autologous nonfrozen bone marrow rescue.
大剂量化疗及自体非冷冻骨髓挽救后的造血重建
Ann Hematol. 1991 Nov;63(5):253-8. doi: 10.1007/BF01698374.