Tan Xingle, Lv Cunming, Lu Chao, Luo Yanan, Mei Zhi-Gang
Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, China.
The Second People's Hospital of Yichang, China Three Gorges University, Yichang, China.
Front Nutr. 2025 Feb 25;12:1512165. doi: 10.3389/fnut.2025.1512165. eCollection 2025.
The serum albumin-to-globulin ratio (A/G) has been widely used as a biomarker to assess inflammation, immunity, and nutritional status. However, relatively few studies have been conducted on the predictive value of serum A/G in stroke. Therefore, this study aimed to evaluate the correlation between serum A/G levels and stroke prognosis, to provide a new reference for risk assessment and management of stroke patients.
Data were sourced from the National Health and Nutrition Examination Survey (NHANES) for 2009-2020. The study utilized questionnaire responses and 24-h dietary recall interviews. Participants were stratified by serum albumin/globulin (A/G) ratios into tertiles. Multivariable logistic regression, curve fitting, subgroup analyses, and interaction tests were conducted to assess the associations with serum A/G ratios.
Of the 82,298 participants initially considered, 52,119 had complete data and no history of stroke, albumin, or globulin deficiency, which were included in the analysis. We observed a decrease in stroke incidence with increasing A/G ratios. Higher A/G ratios were also associated with lower incidences of moderate exercise, diabetes, and coronary heart disease. The relationship between A/G ratios and stroke was moderated by covariates such as gender, hypertension, diabetes, smoking, and body mass index.
In the US population, serum A/G ratios positively correlate with stroke incidence. Serum A/G could be a simple and economical marker for identifying stroke risk in the population, though further prospective studies are required to validate these findings.
血清白蛋白与球蛋白比值（A/G）已被广泛用作评估炎症、免疫和营养状况的生物标志物。然而，关于血清A/G在中风预测价值方面的研究相对较少。因此，本研究旨在评估血清A/G水平与中风预后之间的相关性，为中风患者的风险评估和管理提供新的参考依据。
数据来源于2009 - 2020年美国国家健康与营养检查调查（NHANES）。该研究采用问卷调查回复和24小时饮食回顾访谈。参与者按血清白蛋白/球蛋白（A/G）比值分层为三分位数。进行多变量逻辑回归、曲线拟合、亚组分析和交互作用检验，以评估与血清A/G比值的关联。
在最初考虑的82298名参与者中，52119名有完整数据且无中风、白蛋白或球蛋白缺乏病史，这些被纳入分析。我们观察到随着A/G比值升高，中风发病率降低。较高的A/G比值还与中度运动、糖尿病和冠心病的较低发病率相关。A/G比值与中风之间的关系受到性别、高血压、糖尿病、吸烟和体重指数等协变量的调节。
在美国人群中，血清A/G比值与中风发病率呈正相关。血清A/G可能是一种用于识别群体中风风险的简单且经济的标志物，不过需要进一步的前瞻性研究来验证这些发现。
