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CXCL13、超敏C反应蛋白（HS-CRP）和白细胞计数的综合多生物标志物组合可预测接受高压氧（HBO）和经颅超声神经肌肉电刺激（TUS-NMES）治疗的中风型神经梅毒患者的预后。

Integrated multi-biomarker panel of CXCL13, HS-CRP, and WBC counts predicts outcomes in stroke neurosyphilis patients treated with HBO and TUS-NMES.

作者信息

He Wenchao, Chen Shuangshuang, Chen Ruyang, Zhang Jun, Zhang Xuehua, Wu Minzhi, Zhang Dan, Zhu Fengfeng, He Fanghua, Xv Yating, Lei Na, Zheng Wenhui, Shan Xinyi, Dai Jun

机构信息

Department of Rehabilitation, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.

Hospital Department, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.

出版信息

Front Neurol. 2025 Feb 25;16:1530447. doi: 10.3389/fneur.2025.1530447. eCollection 2025.

DOI:10.3389/fneur.2025.1530447
PMID:40070668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11894733/
Abstract

BACKGROUND

Neurosyphilis results from invading the central nervous system, leading to severe neurological issues like stroke. Combining hyperbaric oxygen (HBO) therapy and transcranial ultrasound neuromuscular stimulation (TUS-NMES) shows promise in improving outcomes.

OBJECTIVE

This study evaluates the predictive value and clinical significance of CXCL13, WBC, and Hs-CRP levels in neurosyphilis patients undergoing HBO and TUS-NMES therapy.

METHODS

The study included 158 neurosyphilis stroke patients treated from June 2022 to January 2024. Assessments of limb motor, cognitive functions, daily living abilities, and cerebrospinal fluid biomarkers were conducted pre- and post-four weeks of combined therapy.

RESULTS

After treatment, there was a significant improvement in FMA, MoCA, and MBI scores ( < 0.001). CXCL13 levels significantly decreased post-treatment, correlating with improved patient outcomes. The study found strong predictive values for CXCL13 levels in determining the efficacy of rehabilitation, with the combination of CXCL13, WBC, and Hs-CRP showing the highest predictive accuracy.

CONCLUSION

HBO and TUS-NMES significantly enhance recovery in neurosyphilis stroke patients. CXCL13, WBC, and Hs-CRP effectively predict rehabilitation outcomes, highlighting their value in clinical management.

摘要

背景

神经梅毒是由梅毒螺旋体侵犯中枢神经系统引起的，可导致中风等严重神经问题。高压氧（HBO）治疗与经颅超声神经肌肉刺激（TUS-NMES）联合应用在改善治疗效果方面显示出前景。

目的

本研究评估CXCL13、白细胞（WBC）和超敏C反应蛋白（Hs-CRP）水平在接受HBO和TUS-NMES治疗的神经梅毒患者中的预测价值及临床意义。

方法

该研究纳入了2022年6月至2024年1月期间接受治疗的158例神经梅毒中风患者。在联合治疗前及治疗四周后，对患者的肢体运动、认知功能、日常生活能力和脑脊液生物标志物进行评估。

结果

治疗后，FMA、MoCA和MBI评分有显著改善（<0.001）。治疗后CXCL13水平显著降低，且与患者病情改善相关。研究发现CXCL13水平在确定康复疗效方面具有较强的预测价值，CXCL13、WBC和Hs-CRP联合应用时预测准确性最高。

结论

HBO和TUS-NMES可显著促进神经梅毒中风患者的恢复。CXCL13、WBC和Hs-CRP能有效预测康复结局，凸显了它们在临床管理中的价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d4/11894733/88f324eecc0a/fneur-16-1530447-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d4/11894733/bf857a64b138/fneur-16-1530447-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d4/11894733/a09b2f43740a/fneur-16-1530447-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d4/11894733/204012ef1e54/fneur-16-1530447-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d4/11894733/88f324eecc0a/fneur-16-1530447-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d4/11894733/bf857a64b138/fneur-16-1530447-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d4/11894733/a09b2f43740a/fneur-16-1530447-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d4/11894733/204012ef1e54/fneur-16-1530447-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d4/11894733/88f324eecc0a/fneur-16-1530447-g004.jpg

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