高压氧治疗有一席之地吗？

Is There a Place for Hyperbaric Oxygen Therapy?

机构信息

University of Maryland Medical Center, Hyperbaric and Dive Medicine, 22 South Greene Street, Baltimore, MD 2120, USA.

University of Maryland School of Medicine, 685 West Baltimore Street, Suite 150, Baltimore, MD 21201, USA.

出版信息

Adv Surg. 2022 Sep;56(1):169-204. doi: 10.1016/j.yasu.2022.02.011.

DOI:10.1016/j.yasu.2022.02.011

PMID:36096567

Abstract

Hyperbaric oxygen therapy (HBOT) involves treating patients by providing 100% oxygen through inhalation while inside a treatment pressurized chamber. The oxygen acts as a drug and the hyperbaric chamber as the dosing device. The effect of hyperbaric hyperoxia is dose dependent and, therefore, treatment depth and duration are important when considering its use. HBOT can either be the primary method of treatment or used adjunctively to medications or surgical techniques. The underpinning physiology is to bring oxygen-rich plasma to hypoxic tissue, preventing reperfusion injury, strengthening immune responsiveness, and encouraging new collagen deposition as well as endothelial cell formation.

摘要

高压氧治疗（HBOT）通过在治疗加压舱内吸入 100%氧气来治疗患者。氧气作为药物，高压舱作为给药装置。高压氧的作用与剂量有关，因此，在考虑使用高压氧治疗时，治疗深度和持续时间很重要。高压氧治疗既可以作为主要治疗方法，也可以与药物或手术技术联合使用。其基础生理学是将富含氧气的血浆输送到缺氧组织，防止再灌注损伤，增强免疫反应，并促进新的胶原蛋白沉积和内皮细胞形成。